Results 71 to 80 of about 45,635 (266)
Advanced Science, EarlyView.CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley +1 more source
Advanced Science, EarlyView.Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao +15 more
wiley +1 more source
Partecipazione e ConflittoThe article contributes to the study of the intersections between institutional and non-institutional politics through an analysis of politicians from activist backgrounds who continue to cooperate with social movements while in office. Previous research
Mari Kuukkanen
doaj +1 more source
Political Communication in Disasters: A Question of Relationships
Culture Unbound: Journal of Current Cultural Research, 2015 Politicians are both a help and hindrance in the provision of information to the public before, during and after disasters. For example, in Australia, the Premier of the State of Queensland, Anna Bligh, was lauded for her leadership and public ...
Hamish McLean, Jacqui Ewart
doaj +1 more source
Advanced Science, EarlyView.Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu +5 more
wiley +1 more source
International Journal of Communication, 2021 Social scientists have long studied international differences in political culture and communication. An influential strand of theory within political science argues that different types of political systems generate different parliamentary cultures ...
Livia van Vliet +2 more
doaj
Advanced Science, EarlyView.After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma +12 more
wiley +1 more source
Advanced Science, EarlyView.A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang +8 more
wiley +1 more source
SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition
Advanced Science, EarlyView.The SEC promotes cell identity transitions by facilitating transcription pause release at key identity‐associated genes, including Klf4 and Myc during iPSC reprogramming and Nes and Tubb3 during ESC‐to‐neuroectodermal differentiation. During early iPSC reprogramming, this function additionally involves cooperation with METTL3‐associated m6A regulation.
Zhijing Zhang +9 more
wiley +1 more source