Results 81 to 90 of about 6,700,494 (391)
FEBS Open Bio, EarlyView.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source
Patron-client relationship in the Rohingya camps: recent trends and impact on refugee governance
Journal of International Humanitarian ActionBangladesh’s rapidly increasing population is putting immense pressure on its resources. Additionally, the country bears the responsibility of providing shelter and protection to millions of Rohingya refugees.
Nurul Huda Sakib +2 more
doaj +1 more source
Bulletin of "Carol I" National Defense UniversityNigeria has been entrapped in a cycle of insecurity which has not only affected the lives and properties of its citizens, but as had a colossal effect on the macro-economy of the state.
Ibrahim O. SALAWU +3 more
doaj +1 more source
Young people and politics in Britain [PDF]
, 2014 Politicians and the media claim that young people are apathetic towards politics, and the turnout among young voters appears to confirm this. But are young people really not interested in politics — or are they simply disenchanted with aspects of the ...
Foard, N, Henn, M
core
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Bringing Gender In? EU Foreign and Security Policy after Brexit
Politics and Governance, 2019 In this article, we identify Brexit as a critical juncture, wherein the EU has had the opportunity to reflect on and reinforce its identity, as a promoter of gender issues within the security domain.
Toni Haastrup +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp +13 more
wiley +1 more source
Tensions in Young People's Conceptualisation and Practice of Politics [PDF]
Young people have been characterised as apathetic and disengaged from mainstream politics. This discourse draws upon a narrow, regulatory and hegemonic model of politics that centres on parliamentary politics.
Nathan Manning
core
A faded passion? Estes Kefauver and the senate subcommittee on antitrust and monopoly [PDF]
, 2007 In this paper I examine the U.S. Senate subcommittee on antitrust and monopoly (1957-1963), chaired by Tennessee Senator Estes Kefauver. I assess the persistence into the postwar years of the antimonopoly critique of bigness that had animated the ...
Scroop, D.
core
FEBS Open Bio, EarlyView.Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani +7 more
wiley +1 more source