Results 41 to 50 of about 1,568,628 (279)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Political Trade-Offs: Democracy and Governance in a Changing World
Politics and Governance, 2019 The investigation of trade-offs in political science receives only limited attention, although many scholars acknowledge the importance of trade-offs across a variety of different areas. A systematic and comprehensive examination of the topic is missing.
Todd Landman, Hans-Joachim Lauth
doaj +1 more source
Religions, 2023 This paper discusses the innovativeness of the Inheritance Ordinance introduced in Toledo during the 12th century and later reintroduced in Fez in Morocco following the expulsion of Jewish communities from Spain and Portugal. Community leaders in Toledo,
Pinhas Haliwa
doaj +1 more source
Indiana Territory and Early Statehood, 1800-1825 [PDF]
, 1987 This handbook was developed to encourage more effective state citizenship through the teaching of state history. Attention is given to geographical factors, politics, government, social and economic changes, and cultural ...
Geib, George W.
core +1 more source
The 1972 miners' strike: popular agency and industrial politics in Britain [PDF]
, 2006 The national miners' strike of 1972 is central to contemporary British history: it undermined Edward Heath's Conservative government and sharpened social conflict; the common interpretation of the strike as a 'victory for violence', shown here to be ...
Phillips, J.
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
From "Ethnocracity" to Urban Apartheid: A View from Jerusalem\al-Quds
Cosmopolitan Civil Societies: An Interdisciplinary Journal, 2016 In the core of this article stands an argument that while ethnocracy was a relevant analytical framework for understanding the urban dynamics of Jerusalem\al-Quds up until two decades ago, this is no longer the case. As this article demonstrates, ver the
Haim Yacobi
doaj +1 more source
The politics of being an educational researcher: minimising the harm done by research. [PDF]
, 2010 Researchers have an obligation to reflect on the politics of their research and of whose interests it serves in order to take steps to minimise it being used in damaging ways. This article uses the problem of the "politics of blame"-- the way governments
Thrupp, Martin
core +2 more sources
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source