Results 71 to 80 of about 783,163 (238)
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Evolución del papel de las entidades de acción social y del educador social en la atención de los Menores Migrantes no Acompañados [PDF]
El fenomen dels menors migrants no acompanyats (MMNA) és relativament recenten el nostre estat de benestar, i ha arribat a posar en dubte les premisses d’atenció a la infància desemparada.
González Morán, Alicia
core
Letting the Future In: a therapeutic intervention for children affected by sexual abuse and their carers:An evaluation of impact and implementation [PDF]
, 2016 Letting the Future In is a structured guide to therapeutic intervention with children affected by sexual abuse. The guide was developed by the NSPCC and has been implemented by 20 NSPCC teams across England, Wales and Northern Ireland since 2011.
Carpenter, John +4 more
core
Learners’ perspectives on school safety in Johannesburg [PDF]
, 2022 In this article we report on a South African study conducted with 1,779 learners aged 11 to 18 years from 8 schools in urban areas in and around Johannesburg.
Errington, Sheri +2 more
core +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
The forensic implications of camouflaging: victimisation and offending in Autism and Pathological Demand Avoidance [PDF]
, 2021 Social camouflaging refers to behaviours or strategies which conceal an individuals’ Autism from others. Camouflaging has also been described by individuals with Pathological Demand Avoidance (PDA). Camouflaging is reportedly used in response to threat,
Trundle, Grace
core
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source