Results 321 to 330 of about 3,561,143 (397)

Physical and Enzymatic Studies on Poly d(I–C).Poly d(I–C), an Unusual Double-helical DNA

Nature, 1970
X-ray diffraction and circular dichroism studies indicate that poly d(I–C).poly d(I–C) exists in a new polynucleotide configuration—an eight-fold helix, possibly left-handed.
Y, Mitsui, R, Langridge, B E, Shortle, C R, Cantor, R C, Grant, M, Kodama, R D, Wells   +6 more
openaire   +2 more sources

Poly I : C in herpetic keratitis in rabbits

Experimental Eye Research, 1974
Abstract Herpetic keratoconjunctivitis, induced in rabbit eyes, was experimentally treated with poly-inosinic and poly-cytidilic acid (poly I : C), idoxuridine (IDU) and a combination thereof. It appeared that IDU 0·1% four times daily and poly I:C 1 mg/ml twice daily combined are more effective than either IDU four times daily or poly I:C twice or ...
J A, Oosterhuis, W A, Nolen, S H, Sie, J, Versteeg   +3 more
openaire   +2 more sources

Penetrating Spherulitic Growth in Poly(butylene adipate-co-butylene succinate)/Poly(ethylene oxide) Blends

Macromolecules, 2005
The spherulitic growth of poly(ethylene oxide) (PEO) was found to continue in the spherulites of poly(butylene adipate-co-butylene succinate) (PBAS) in the simultaneous spherulitic growth process of the two components in PBAS/PEO blends. This phenomenon, namely the formation of interpenetrating spherulites (IPS), was analyzed on the basis of ...
Takayuki Ikehara, Hironori Kimura, Zhaobin Qiu   +2 more
openaire   +1 more source

Immunologically active ferumoxytol-poly(I : C) nanomaterials inhibit metastatic melanoma by regulating myeloid-derived suppressor cell differentiation

Biomaterials Science, 2023
FP-NPs inhibit metastatic melanoma by promoting MDSC differentiation to M1 macrophages.
Gaochuan Fang, Zhonghai Zhang, Bo Jiang, Yunuo Zheng, Xufeng Xiao, Tianlong Wang, Zhengkui Zhang, Jiaojiao Zhao   +7 more
openaire   +2 more sources

Critical Strains in Poly(ε-caprolactone) and Blends with Poly(vinyl methyl ether) and Poly(styrene-co-acrylonitrile)

Macromolecules, 2003
The deformation properties under a tensile load of poly(e-caprolactone) (PCL) were compared to those of PCL/PVME and PCL/SAN mixtures. The critical strains at the end of the Hooke range (point A) and at the yield point (point B) remain unchanged. The critical strain marking the beginning of a disintegration of the blocklike crystallites and a fibril ...
Y. Men, G. Strobl
openaire   +1 more source

Prophylactic effect of pectic oligosaccharides against poly I: C‐ induced virus‐like infection in BALB/c mice

Journal of Food Biochemistry, 2022
Pectin oligosaccharides (POS) are pectin-derived prebiotics that exerts anti-inflammatory effects on the host and stimulates an innate immune response. The role of POS in protective immunity against viral infections is not very obvious. Therefore, the prophylactic effect of POS in the mouse model induced by Poly I: C mimicking viral infection was ...
Nidhi Sori, Saarika Pothuvan Kunnummal, MuthuKumar Serva Peddha, Mahejibin Khan   +3 more
openaire   +2 more sources

Occurrence of Radical Cation Localization in Chemically Modified Poly(methylphenylsilane):  Poly(methylphenyl-co-4-dimethylaminophenylmethylsilane)s and Poly(methylphenyl-co-4-bromophenylmethylsilane)s

Chemistry of Materials, 1999
Chemical modification of poly(methylphenylsilane) 1 using triflate chemistry gave two series of random copolymers with different composition ratios, viz., poly(methylphenyl-co-4-dimethylaminophenylmethylsilane)s 3-7 and poly(methylphenyl-co-4-bromophenylmethylsilane)s 8-9.
Cleij, TJ, King, JK, Jenneskens, LW
openaire   +2 more sources

Optimization of an immunotherapeutic protocol with poly(I,C)-LC.

Journal of biological response modifiers, 1986
The development of successful immunotherapeutic protocols requires new therapeutic strategies as well as the development of clinically predictive tumor models and protocols. A bell-shaped response curve is observed with many biological response modifiers (BRMs), not only for immunomodulation, but also for therapeutic activity.
J E, Talmadge, D, Hartmann
openaire   +1 more source

Immunomodulatory effects of poly(I,C)-LC in cancer patients.

Journal of biological response modifiers, 1986
Poly(I,C)-LC was administered in low (1 mg/m2) and intermediate (4 mg/m2) doses to cancer patients by intramuscular injection or intravenous infusion to evaluate the immunomodulatory effects. Natural killer cell (NK) activity was elevated slightly at the low dose and remained unchanged overall, but some depression was observed at the 4 mg/m2 ...
A E, Maluish, J W, Reid, E A, Crisp, W R, Overton, H, Levy, K A, Foon, R B, Herberman   +6 more
openaire   +1 more source

Role of nitric oxide in poly(I-C)-induced endothelial cell expression of leukocyte adhesion molecules

American Journal of Physiology-Heart and Circulatory Physiology, 1997
Polyinosinic-polycytidylic acid [poly(I-C)] is a synthetic double-stranded RNA (dsRNA) that simulates a viral-infected state in cells. It has been shown that viral infection, as well as poly(I-C), stimulates leukocyte adhesion to endothelial cell (EC) monolayers and that this is mediated through the surface expression of the adhesion molecules E ...
T R, Faruqi, S C, Erzurum, F T, Kaneko, P E, DiCorleto   +3 more
openaire   +2 more sources