Results 211 to 220 of about 303,632 (262)
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Rusfertide, a Hepcidin Mimetic, for Control of Erythrocytosis in Polycythemia Vera.
New England Journal of MedicineBACKGROUND Polycythemia vera is a chronic myeloproliferative neoplasm characterized by erythrocytosis. Rusfertide, an injectable peptide mimetic of the master iron regulatory hormone hepcidin, restricts the availability of iron for erythropoiesis.
M. Kremyanskaya +18 more
semanticscholar +3 more sources
Cancer Cell, 2005
Polycythemia vera (PV), essential thrombocythemia (ET), and myeloid metaplasia with myelofibrosis (MMM) are clonal disorders arising from hematopoietic progenitors.
R. Levine +28 more
semanticscholar +3 more sources
Polycythemia vera (PV), essential thrombocythemia (ET), and myeloid metaplasia with myelofibrosis (MMM) are clonal disorders arising from hematopoietic progenitors.
R. Levine +28 more
semanticscholar +3 more sources
Hematology/Oncology Clinics of North America, 2003
The differential diagnosis of an elevated hematocrit and the criteria for the diagnosis of polycythemia vera present little or no problem; however, there is not a consensus on therapy. Spivak likened this to a conundrum--"an intricate and difficult problem." Nonetheless, it can be argued that on the basis of the following criteria--life expectancy, the
Nathanial, Berlin, Nathanial I, Berlin
+9 more sources
The differential diagnosis of an elevated hematocrit and the criteria for the diagnosis of polycythemia vera present little or no problem; however, there is not a consensus on therapy. Spivak likened this to a conundrum--"an intricate and difficult problem." Nonetheless, it can be argued that on the basis of the following criteria--life expectancy, the
Nathanial, Berlin, Nathanial I, Berlin
+9 more sources
Internal and Emergency Medicine, 2010
The diagnostic approach to a patient with polycythemia has been greatly simplified by the introduction of new genetic testing in addition to traditional tests, such as measurement of red cell mass and serum erythropoietin (Epo) level. Clonal erythrocytosis, which is the diagnostic feature of polycythemia vera (PV), is almost always associated with a ...
Raffaele, Landolfi +3 more
+7 more sources
The diagnostic approach to a patient with polycythemia has been greatly simplified by the introduction of new genetic testing in addition to traditional tests, such as measurement of red cell mass and serum erythropoietin (Epo) level. Clonal erythrocytosis, which is the diagnostic feature of polycythemia vera (PV), is almost always associated with a ...
Raffaele, Landolfi +3 more
+7 more sources
Hepcidin mimetics in polycythemia vera: resolving the irony of iron deficiency and erythrocytosis
Current opinion in hematology, 2022Purpose of review Development of hepcidin therapeutics has been a ground-breaking discovery in restoring iron homeostasis in several haematological disorders.
S. Handa +3 more
semanticscholar +1 more source
Disease-a-Month, 1992
Polycythemia vera (PV) is one of the myeloproliferative diseases, and, as such, is an example of clonal hematopoiesis. The progeny of a single, abnormal, hematopoietic stem cell gain a growth advantage over their normal counterparts resulting in overproduction of red cells generally accompanied by overproduction of granulocytes and platelets as well ...
DEWOLF, JTM, VELLENGA, E, HALIE, MR
openaire +4 more sources
Polycythemia vera (PV) is one of the myeloproliferative diseases, and, as such, is an example of clonal hematopoiesis. The progeny of a single, abnormal, hematopoietic stem cell gain a growth advantage over their normal counterparts resulting in overproduction of red cells generally accompanied by overproduction of granulocytes and platelets as well ...
DEWOLF, JTM, VELLENGA, E, HALIE, MR
openaire +4 more sources
Journal of the American Academy of Nurse Practitioners, 1999
Although no cure exists for PV, treatment can prolong lives and enhance the quality-of-life for patients affected by this condition (Talarico, 1998). The insidious onset may make diagnosis difficult, but PV should be suspected when any patient presents with an elevated hematocrit.
Kerri Lantz Petersen, Lorna Schumann
openaire +2 more sources
Although no cure exists for PV, treatment can prolong lives and enhance the quality-of-life for patients affected by this condition (Talarico, 1998). The insidious onset may make diagnosis difficult, but PV should be suspected when any patient presents with an elevated hematocrit.
Kerri Lantz Petersen, Lorna Schumann
openaire +2 more sources
Current Treatment Options in Oncology, 2018
Polycythemia vera (PV) is the most common myeloproliferative neoplasm (MPN), the ultimate phenotype of the JAK2 V1617F mutation, the MPN with the highest incidence of thromboembolic complications, which usually occur early in the course of the disease, and the only MPN in which erythrocytosis occurs. The classical presentation of PV is characterized by
openaire +2 more sources
Polycythemia vera (PV) is the most common myeloproliferative neoplasm (MPN), the ultimate phenotype of the JAK2 V1617F mutation, the MPN with the highest incidence of thromboembolic complications, which usually occur early in the course of the disease, and the only MPN in which erythrocytosis occurs. The classical presentation of PV is characterized by
openaire +2 more sources