Results 71 to 80 of about 24,891 (262)

DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy

Advanced Science, EarlyView.
Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi, Fei Li, Heng Jiang, Lingling Gu, Mengjie Sun, Kunyu Lu, Pianpian Liu, Ruyue Xie, Wenqiang Ma, Meijuan Zheng, Xianwei Wang, Xuefu Wang, Jingjing Cong   +12 more
wiley   +1 more source

Tailoring the surface charge of dextran-based polymer coated SPIONs for modulated stem cell uptake and MRI contrast [PDF]

, 2015
Tracking stem cells in vivo using non-invasive techniques is critical to evaluate the efficacy and safety of stem cell therapies. Superparamagnetic iron oxide nanoparticles (SPIONs) enable cells to be tracked using magnetic resonance imaging (MRI), but ...
Adams, Dave J., Barrow, Michael, Bogart, Lara K., Chalmers, Jeffrey J., Collins, Christopher M., Lévy, Raphaël, Mandal, Pranab, Moore, Lee R., Murray, Patricia, Nieves, Daniel J., Rosseinsky, Matthew J., Taylor, Arthur, Williams, Steve R.   +12 more
core   +2 more sources

Profiling Localized Immunomodulation and Drug Biodistribution within a Subcutaneous Vascularized Niche for Cell Transplantation

Advanced Science, EarlyView.
We studied how five common immunosuppressants behave when delivered directly to a transplant site instead of systemically. Using a vascularized implant for islet transplantation, we show that local delivery protects grafts, limits drug spread to the rest of the body, and produces distinct immune signatures.
Jocelyn Nikita Campa‐Carranza, Simone Capuani, Melissa A. Willman, Alexander Rabassa, Ashley L. Joubert, Tommaso Bo, Letizia Franco, Marzia Conte, Ana L. Anaya‐García, Gabrielle E. Rome, Rim Ouni, Henry J. Seaborne, Camden A. Caffey, Dora M. Berman, Junjun Zheng, Jesus Paez‐Mayorga, Corrine Ying Xuan Chua, Shu Hsia Chen, Norma S. Kenyon, Alessandro Grattoni   +19 more
wiley   +1 more source

PES-Kaolin Mixed Matrix Membranes for Arsenic Removal from Water

Membranes, 2017
The aim of this work was the fabrication and the characterization of mixed matrix membranes (MMMs) for arsenic (As) removal from water. Membrane separation was combined with an adsorption process by incorporating the kaolin (KT2) Algerian natural clay in
Tiziana Marino, Francesca Russo, Lina Rezzouk, Abderrazak Bouzid, Alberto Figoli   +4 more
doaj   +1 more source

A fully integrated paperfluidic molecular diagnostic chip for the extraction, amplification, and detection of nucleic acids from clinical samples [PDF]

, 2016
Paper diagnostics have successfully been employed to detect the presence of antigens or small molecules in clinical samples through immunoassays; however, the detection of many disease targets relies on the much higher sensitivity and specificity ...
Dewar, Rajan, Klapperich, Catherine, Liu, Lena, Rodriguez, Natalia Maria, Wong, Winnie S.   +4 more
core   +2 more sources

Reconstructed Polyamide Nanolayers via Two‐Stage Interfacial Polymerization Engineering for Precise Ion Sieving

Advanced Science, EarlyView.
A reconstructed polyamide nanofiltration membrane is engineered via a two‐stage interfacial polymerization strategy for lithium extraction from complex brines. Incorporated bidentate quaternary ammonium monomers enable synergistic steric and electrostatic effects within sub‐nanometer channels, achieving 60‐fold lithium enrichment and demonstrating ...
Shuzhen Zhao, Liheng Dai, Feidong Yang, Bowen Li, Pengfei Zhang, Yanyan Liu, Mengyang Hu, Kecheng Guan, Ryosuke Takagi, Hideto Matsuyama   +9 more
wiley   +1 more source

Comparison between a Conventional Anti-Biofouling Compound and a Novel Modified Low-Fouling Polyethersulfone Ultrafiltration Membrane: Bacterial Anti-Attachment, Water Quality and Productivity

Membranes, 2020
In this work, the efficiency of a conventional chlorination pretreatment is compared with a novel modified low-fouling polyethersulfone (PES) ultrafiltration (UF) membrane, in terms of bacteria attachment and membrane biofouling reduction.
Norhan Nady, Noha Salem, Ranya Amer, Ahmed El-Shazly, Sherif H. Kandil, Mohamed Salah El-Din Hassouna   +5 more
doaj   +1 more source

SYNTHESIS AND CHARACTERIZATION OF POLYIMIDEZEOLITE MIXED MATRIX MEMBRANE FOR BIOGAS PURIFICATION [PDF]

, 2009
Biogas has become an attractive alternative energy source due to the limitation of energy from fossil. In this study, a new type of mixed matrix membrane (MMM) consisting of polyimide-zeolite was synthesized and characterized for biogas purification ...
Budiyono, Budiyono, I.N. , Widiasa, Seno, Johari, Sunarso, Sunarso, Tutuk Joko, Kusworo   +4 more
core  

Molecularly Bridged Heterointerface Engineering: Designing Transparent, Wear‐Resistant, Hard yet Flexible Optoelectronic Protective Film

Advanced Science, EarlyView.
A molecular‐bridging heterogeneous interface engineering strategy is introduced to combine a polyhedral oligomeric silsesquioxane (POSS)‐based hard coating with a colorless polyimide (CPI)‐based flexible layer. The robust heterogeneous interface endows the integrated system with the superior properties of both layers and their synergistic ...
Huiyang Lu, Zihui Liu, Jianan Yuan, Yunhao Wei, Shuangfei Xiang, Qinghua Lu   +5 more
wiley   +1 more source

Why on earth do we need experiments to choose the right membrane? [PDF]

, 2009
Ultrafiltration (UF) is a relatively inexpensive, versatile, expedient, simple, non destructive, and reagent free technique for fractionating biological solutions in order to purify and concentrate high added value compounds.
Belleville, Marie-Pierre, Doco, Thierry, Dornier, Manuel, Ortiz-Basurto, Rosa Isela, Pourcelly, Gérald, Williams, P.   +5 more
core