Results 111 to 120 of about 16,172 (236)

Impact of molecular weight on the mechanism of cellular uptake of polyethylene glycols (PEGs) with particular reference to P-glycoprotein. [PDF]

Acta Pharm Sin B, 2020
Wang T, Guo Y, He Y, Ren T, Yin L, Fawcett JP, Gu J, Sun H.   +7 more
europepmc   +1 more source

Magnetically Actuated Microrobot for Drug Delivery: Current Progress and Challenges

Advanced Robotics Research, EarlyView.
Magnetically actuated microrobots are reshaping targeted drug delivery through wireless propulsion, programmable materials, and localized therapeutic release. This review examines how fabrication, body material selection, structural architecture, loading mechanisms, and imaging‐guided control converge to enable microrobotic therapies while identifying ...
Yang Yang, David J. Cappelleri
wiley   +1 more source

Advanced Flexible Robotic Systems for the Early Diagnosis and Treatment of Cancer and Cardiovascular Diseases

Advanced Robotics Research, EarlyView.
Flexible surgical robots are advancing minimally invasive interventions for cardiovascular diseases and cancer by enabling precise navigation through complex, submillimeter anatomical pathways. This review highlights recent innovations in actuation, bio‐integrated sensing, AI‐assisted control, and friction‐reduction technologies, discusses current ...
Hermione Truong, Chi Cong Nguyen, Hannah Thuy Truong, Kefan Zhu, Adrienne Ji, James Davies, Emanuele Nicotra, Bibhu Sharma, Jingjing Wan, Patrick Pruscino, Shing Wai Wong, Hoang‐Phuong Phan, Phuoc Thien Phan, Nigel H. Lovell, Thanh Nho Do   +14 more
wiley   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Anti-Cancer Activities of Thyrointegrin α_vβ₃ Antagonist Mono- and Bis-Triazole Tetraiodothyroacetic Acid Conjugated via Polyethylene Glycols in Glioblastoma.

Cancers (Basel), 2021
Godugu K, Rajabi M, Mousa SA.
europepmc   +1 more source

Friend, Not Foe: Lowered Tissue Reactivity to Long‐Term Polyimide Implants

Advanced Science, EarlyView.
The choice of optimal neural probe designs remains a major challenge in the field of neurotechnology. This study investigated the biocompatibility of several probe variations, including material, thickness, width, and implantation strategy. It highlights the clear advantage of soft polyimide probes over stiff silicon probes for better device ...
Corinne Orlemann, Laura M. De Santis, Paul Neering, Christian Boehler, Kirti Sharma, Arno Aarts, Tobias Holzhammer, Rik J. J. van Daal, Patrick Ruther, Maria Asplund, Roxana N. Kooijmans, Pieter R. Roelfsema   +11 more
wiley   +1 more source

Oral absorption of high molecular weight polyethylene glycols: mechanistic, safety and regulatory insights. [PDF]

Front Drug Saf Regul
Gennari CGM, Azari S, Casiraghi A, Musazzi UM.   +3 more
europepmc   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Regiochemical Control in a Thiol-Epoxy 'Click' Reaction: Synthesis of Cysteine and Glutathione Chain-End Functionalized Polyethylene Glycols. [PDF]

Polymers (Basel)
Grad O, Socaci C, Lazar MD, Pîrnău A, Khan A.   +4 more
europepmc   +1 more source