Results 171 to 180 of about 40,214 (287)
Existentialism and My ‘Postwolf’ Dachshund: Authenticity in the Age of Genetic Engineering
ABSTRACT Human genetic engineering has the potential to profoundly alter the traits of future generations, raising critical ethical questions about authenticity and identity. Essentialist perspectives reject genetic engineering, claiming it inherently compromises authenticity by deviating from a species‐typical genome.
Donrich Thaldar
wiley +1 more source
Correction: Validation of a genome-wide polygenic score for body mass index in South Asians. [PDF]
Menon R +13 more
europepmc +1 more source
Gljúfurárjökull, located on the Tröllaskagi Peninsula in northern Iceland, is a small glacier approximately 3.8 km in length. This study analyses the glacier's evolution through a combination of methods including: (i) geomorphological mapping, (ii) Cosmic‐Ray Exposure (CRE) dating, (iii) lichenometry and (iv) palaeoglacier reconstruction (volume ...
Nuria Andrés +14 more
wiley +1 more source
Multiple polygenic score approach in colorectal cancer risk prediction. [PDF]
Jiang SJ +43 more
europepmc +1 more source
The use of different types of networks, alone and in combination, for drug target identification
Current therapeutic approaches often focus on targeting clinical symptoms or peripheral phenotypes rather than the underlying molecular mechanisms, or endophenotypes, that drive diseases. While symptom‐based drugs can alleviate discomfort, they do not necessarily alter disease progression and may overlook opportunities for prevention or early ...
Paolo Parini
wiley +1 more source
The relationship between polygenic risk scores and cognition in Schizophrenia
Richards A.L +50 more
openalex +1 more source
Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen +2 more
wiley +1 more source

