Results 171 to 180 of about 3,197,012 (359)
Sparse whole-genome sequencing identifies two loci for major depressive disorder. [PDF]
Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide, poses a major challenge to genetic analysis.
CONVERGE consortium
core +1 more source
Living at genetic risk: The patient experience of Lynch syndrome
Abstract Lynch syndrome is a germline cancer predisposition syndrome caused by a variant in one of four genes. Lynch syndrome places individuals at significantly higher risk for a range of cancers, especially colorectal and endometrial. Depending on which gene is affected, the risk of ovarian, gastric, small bowel, pancreatic, biliary urothelial, brain,
Nicola Reents +2 more
wiley +1 more source
Thyroid Cancer Polygenic Risk Score Improves Classification of Thyroid Nodules as Benign or Malignant [PDF]
Nikita Pozdeyev +17 more
openalex +1 more source
Fast Genome-Wide QTL Analysis Using Mendel
Pedigree GWAS (Option 29) in the current version of the Mendel software is an optimized subroutine for performing large scale genome-wide QTL analysis.
Hu, Tao +4 more
core
Fast Genome-Wide QTL Association Mapping on Pedigree and Population Data [PDF]
Since most analysis software for genome-wide association studies (GWAS) currently exploit only unrelated individuals, there is a need for efficient applications that can handle general pedigree data or mixtures of both population and pedigree data.
Blangero, John +5 more
core +1 more source
ABSTRACT The role of metabolites in the association between socioeconomic status (SES) and gastric cancer remains unclear. This study seeks to elucidate the role of metabolomics in the association between SES and gastric cancer, as well as to explore potential interactions between metabolic signatures and polygenic risk score (PRS) in the context of ...
Shiyin Meng +8 more
wiley +1 more source
The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia [PDF]
Alexandros Rammos +4 more
openalex +1 more source
Impulsivity and exposure to painful and provocative events each contribute to risk for suicide attempt. However, there is little support for the hypothesis that genetic influences on suicide attempt are mediated by impulsivity and painful and provocative event exposure in early adolescence.
Mallory Stephenson +2 more
wiley +1 more source
This study found that genetic factors largely influence crying duration and settle ability in infancy, while shared environmental factors primarily affect the number of night wakeups. Etiological influences tended to change from 2 to 5 months, reflecting a highly plastic period in infant brain development and in child‐environment interactions. Abstract
Charlotte Viktorsson +5 more
wiley +1 more source

