Results 171 to 180 of about 40,214 (287)

Existentialism and My ‘Postwolf’ Dachshund: Authenticity in the Age of Genetic Engineering

Bioethics, EarlyView.
ABSTRACT Human genetic engineering has the potential to profoundly alter the traits of future generations, raising critical ethical questions about authenticity and identity. Essentialist perspectives reject genetic engineering, claiming it inherently compromises authenticity by deviating from a species‐typical genome.
Donrich Thaldar
wiley   +1 more source

Correction: Validation of a genome-wide polygenic score for body mass index in South Asians. [PDF]

Front Genet
Menon R, Khan N, Charugulla S, Bassi A, Dangare P, Dedaniya A, Pant A, Anjanappa R, Samson PL, Satagopan U, Murugan S, Naikawadi A, Ramprasad VL, Gupta R.   +13 more
europepmc   +1 more source

Polygenic Score for Smoking Is Associated With Externalizing Psychopathology and Disinhibited Personality Traits but Not Internalizing Psychopathology in Adolescence

, 2021
Brian M. Hicks, David A. Clark, Joseph D. Deak, Mengzhen Liu, C. Emily Durbin, Jonathan D. Schaefer, Sylia Wilson, William G. Iacono, Matt McGue, Scott Vrieze   +9 more
openalex   +2 more sources

Late‐Holocene evolution of a small Sub‐Arctic glacier, Gljúfurárjökull (Tröllaskagi, northern Iceland)

Boreas, EarlyView.
Gljúfurárjökull, located on the Tröllaskagi Peninsula in northern Iceland, is a small glacier approximately 3.8 km in length. This study analyses the glacier's evolution through a combination of methods including: (i) geomorphological mapping, (ii) Cosmic‐Ray Exposure (CRE) dating, (iii) lichenometry and (iv) palaeoglacier reconstruction (volume ...
Nuria Andrés, José M. Fernández‐Fernández, David Palacios, Irene Schimmelpfennig, Leopoldo G. Sancho, Skafti Brynjólfsson, Þorsteinn Sæmundsson, Wesley R. Farnsworth, Luis M. Tanarro, Mariano Brito, Javier Santos‐González, Rosa B. González‐Gutiérrez, ASTER Team, Georges Aumaître, Karim Keddadouche   +14 more
wiley   +1 more source

Multiple polygenic score approach in colorectal cancer risk prediction. [PDF]

Sci Rep
Jiang SJ, Thomas M, Rosenthal EA, Phipps AI, Sakoda LC, van Duijnhoven FJB, Pellatt AJ, Avery CL, Berndt SI, Bishop DT, Castellví-Bel S, Chan AT, Grant RC, Gignoux C, Gsur A, Gunter MJ, Haiman CA, Hoffmeister M, Jarvik GP, Jenkins MA, Keku TO, Küry S, Lee JK, Marchand LL, Moreno V, Newcomb PA, Newton CC, Ogino S, Palmer JR, Pearlman R, Qu C, Schoen RE, Um CY, Van Guelpen B, Visvanathan K, Vymetalkova V, White E, Woods MO, Platz EA, Brenner H, Corley DA, Vogelaar IL, Hsu L, Peters U.   +43 more
europepmc   +1 more source

The use of different types of networks, alone and in combination, for drug target identification

British Journal of Pharmacology, EarlyView.
Current therapeutic approaches often focus on targeting clinical symptoms or peripheral phenotypes rather than the underlying molecular mechanisms, or endophenotypes, that drive diseases. While symptom‐based drugs can alleviate discomfort, they do not necessarily alter disease progression and may overlook opportunities for prevention or early ...
Paolo Parini
wiley   +1 more source

The relationship between polygenic risk scores and cognition in Schizophrenia

Richards A.L, Pardiñas A.F, Aura Frizzati, Tansey K.E, Lynham A.J, Peter Holmans, Legge S.E, Savage J.E, Ingrid Agartz, Andreassen O.A, Blokland G.A.M, Aiden Corvin, Donna Cosgrove, F Degenhardt, Srdjan Djurovic, Thomas Espeseth, Laura Ferraro, Charlotte Gayer‐Anderson, Ina Giegling, Van Haren N.E, H M, Hubert J.J, Jönsson E.G, Bettina Konte, Leonhard Lennertz, Loohuis L.M.O, Ingrid Melle, Craig Morgan, Muhamad Isna N W, Murray R.M, Håkan Nyman, Ophoff R.A, Van Ose J, van Os J, Van Osk J., Bloklande G.A.M., Petryshen T.L., Diego Quattrone, Marcella Rietschel, Dan Rujescu, Rutten B.P.F., Fabian Streit, Jana Strohmaier, Sullivan P.F, Kjetil Sundet, Michael Wagner, Valentina Escott‐Price, Owen M.J., Gary Donohoe, O’Donovan M.C., Walters J.T.R.   +50 more
openalex   +1 more source

Genetically-Engineered Begots, Have-Nots, and Tinkered Tots: (High Scoring PolyGenic Kids as a Heredity-Camelot) - An Introduction to the Legalities and Bio-Ethics of Advanced IVF and Genetic Editing

, 2021
Barbara Pfeffer Billauer
openalex   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Neoplasm Polygenic Risk Score [PDF]

, 2020
openaire   +1 more source