Results 171 to 180 of about 3,197,012 (359)

Sparse whole-genome sequencing identifies two loci for major depressive disorder. [PDF]

, 2015
Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide, poses a major challenge to genetic analysis.
CONVERGE consortium
core   +1 more source

Living at genetic risk: The patient experience of Lynch syndrome

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome is a germline cancer predisposition syndrome caused by a variant in one of four genes. Lynch syndrome places individuals at significantly higher risk for a range of cancers, especially colorectal and endometrial. Depending on which gene is affected, the risk of ovarian, gastric, small bowel, pancreatic, biliary urothelial, brain,
Nicola Reents, Georgina Hoffmann, Kelly Kohut   +2 more
wiley   +1 more source

Thyroid Cancer Polygenic Risk Score Improves Classification of Thyroid Nodules as Benign or Malignant [PDF]

, 2023
Nikita Pozdeyev, Manjiri Dighe, Martin Barrio, Christopher D. Raeburn, Harry Smith, M. Fisher, Sameer Chavan, Nicholas Rafaels, Jonathan Shortt, Meng Lin, Michael G. Leu, Toshimasa Clark, Carrie B. Marshall, Bryan R. Haugen, Devika Subramanian, Kristy Crooks, Christopher R. Gignoux, Trevor Cohen   +17 more
openalex   +1 more source

Fast Genome-Wide QTL Analysis Using Mendel

, 2014
Pedigree GWAS (Option 29) in the current version of the Mendel software is an optimized subroutine for performing large scale genome-wide QTL analysis.
Hu, Tao, Lange, Kenneth, Sobel, Eric M, Zhou, Hua, Zhou, Jin   +4 more
core  

Fast Genome-Wide QTL Association Mapping on Pedigree and Population Data [PDF]

, 2014
Since most analysis software for genome-wide association studies (GWAS) currently exploit only unrelated individuals, there is a need for efficient applications that can handle general pedigree data or mixtures of both population and pedigree data.
Blangero, John, Chan, Kei-hang K., Dyer, Thomas D., Lange, Kenneth, Sobel, Eric M., Zhou, Hua   +5 more
core   +1 more source

Socioeconomic Status Modifies the Risk of Gastric Cancer Through Metabolomic Signature: Evidence From a Prospective Cohort Study

iNew Medicine, EarlyView.
ABSTRACT The role of metabolites in the association between socioeconomic status (SES) and gastric cancer remains unclear. This study seeks to elucidate the role of metabolomics in the association between SES and gastric cancer, as well as to explore potential interactions between metabolic signatures and polygenic risk score (PRS) in the context of ...
Shiyin Meng, Shangxin Zhang, Jing Wang, Zhuoyi Wu, Wenjie Xuan, Jiawei Zhang, Qihong Zhao, Anla Hu, Jing Ni   +8 more
wiley   +1 more source

The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia [PDF]

, 2019
Alexandros Rammos, Lara A. Neira Gonzalez, Daniel R. Weinberger, Kevin J. Mitchell, Kristin K. Nicodemus   +4 more
openalex   +1 more source

Genetic influences on suicide attempt in adolescence: Evaluating mediation by impulsivity and painful and provocative events

JCPP Advances, EarlyView.
Impulsivity and exposure to painful and provocative events each contribute to risk for suicide attempt. However, there is little support for the hypothesis that genetic influences on suicide attempt are mediated by impulsivity and painful and provocative event exposure in early adolescence.
Mallory Stephenson, Séverine Lannoy, Alexis C. Edwards   +2 more
wiley   +1 more source

Supplementary Table 3 from Do Polygenic Risk Scores Add to Clinical Data in Predicting Pancreatic Cancer? A Scoping Review

, 2023
Louise Wang, Alyssa Grimshaw, Catherine Mezzacappa, Navid Rahimi Larki, Yu‐Xiao Yang, Amy C. Justice   +5 more
openalex   +1 more source

Genetic and environmental influences on sleep quality, ability to settle, and crying duration in 2‐ and 5‐month‐old infants: A longitudinal twin study

JCPP Advances, EarlyView.
This study found that genetic factors largely influence crying duration and settle ability in infancy, while shared environmental factors primarily affect the number of night wakeups. Etiological influences tended to change from 2 to 5 months, reflecting a highly plastic period in infant brain development and in child‐environment interactions. Abstract
Charlotte Viktorsson, Ashraf Yahia, Mark J. Taylor, Angelica Ronald, Kristiina Tammimies, Terje Falck‐Ytter   +5 more
wiley   +1 more source