Results 311 to 320 of about 2,929,620 (353)

Type 1 diabetes risk factors, risk prediction and presymptomatic detection: Evidence and guidance for screening

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Type 1 diabetes is recognized as a chronic disease with a presymptomatic phase that does not require insulin therapy and a clinical phase where insulin treatment becomes necessary. The presymptomatic phase is characterized by the presence of autoantibodies targeting pancreatic islet beta cell antigens (islet autoantibodies).
Ezio Bonifacio, Anette‐Gabriele Ziegler   +1 more
wiley   +1 more source

Type 1 diabetes presenting in adults: Trends, diagnostic challenges and unique features

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Type 1 diabetes (T1D) has been historically regarded as a childhood‐onset disease; however, recent epidemiological data indicate that adult‐onset T1D accounts for a substantial proportion of cases worldwide. There is evidence that adult‐onset T1D is associated with the classic T1D triad of elevated genetic risk, the presence of islet‐specific ...
Carmella Evans‐Molina, Richard A. Oram
wiley   +1 more source

A polygenic score associated with fracture risk in breast cancer patients treated with aromatase inhibitors. [PDF]

NPJ Breast Cancer
Hook C, Chatterjee U, Sheng H, Zhu Q, Robinson T, Roh JM, Laurent CA, Lee C, Delmerico J, Lo JC, Ambrosone CB, Kushi LH, Kwan ML, Yao S.   +13 more
europepmc   +1 more source

Genome-Wide Polygenic Score for Muscle Strength Predicts Risk for Common Diseases and Lifespan: A Prospective Cohort Study. [PDF]

J Gerontol A Biol Sci Med Sci
Herranen P, Koivunen K, Palviainen T, Kujala UM, Ripatti S, Kaprio J, Sillanpää E, FinnGen.   +7 more
europepmc   +1 more source

Selection for increased sexual bimaturism in the common housefly, Musca domestica

Entomologia Experimentalis et Applicata, EarlyView.
Females and males may have different economic value in insect production. We selected houseflies, Musca domestica (Diptera: Muscidae), for six generations for increased sexual bimaturism by breeding early‐emerging males with late‐emerging females.
Giovanni Petrucci, Ljubinka Francuski, Walter L. Jansen, Leo W. Beukeboom   +3 more
wiley   +1 more source

The interplay between polygenic score for tumor necrosis factor-α, brain structural connectivity, and processing speed in major depression. [PDF]

Mol Psychiatry
Flinkenflügel K, Gruber M, Meinert S, Thiel K, Winter A, Goltermann J, Usemann P, Brosch K, Stein F, Thomas-Odenthal F, Wroblewski A, Pfarr JK, David FS, Beins EC, Grotegerd D, Hahn T, Leehr EJ, Dohm K, Bauer J, Forstner AJ, Nöthen MM, Jamalabadi H, Straube B, Alexander N, Jansen A, Witt SH, Rietschel M, Nenadić I, van den Heuvel MP, Kircher T, Repple J, Dannlowski U.   +31 more
europepmc   +1 more source

Evaluation of polygenic score for hypertrophic cardiomyopathy in the general population and across clinical settings

, 2023
Zheng SL, Jurgens SJ, McGurk KA, Xu X, Grace C, Theotokis PI, Buchan RJ, Francis C, Marvao Ad, Curran L, Bai W, Pua CJ, Chiaw TH, Jorda P, Slegtenhorst MAv, Verhagen JM, Harper AR, Ormondroyd E, Chin CW, Genomics England Research Consortium, HCM GWAS Collaborators, Pantazis A, Baksi J, Halliday BP, Matthews P, Pinto YM, Walsh R, Amin AS, Wilde AA, Cook SA, Prasad SK, Barton PJ, Barton PJ, O’Regan DP, Lumbers R, Goel A, Tadros R, Michels M, Watkins H, Bezzina CR, Ware JS.   +40 more
europepmc   +1 more source

Phenotypic heterogeneity in familial epilepsies is influenced by polygenic risk for generalized and focal epilepsies

Epilepsia, EarlyView.
Abstract Objective Although previous research shows that generalized and focal epilepsies have at least some distinct genetic influences, it remains uncertain why some families manifest both types of epilepsy. We tested two hypotheses: (1) families with both generalized and focal epilepsy carry separate risk alleles for both types; and (2) within mixed
Colin A. Ellis, Ruth Ottman, Michael P. Epstein, Epi4K Consortium, Samuel F. Berkovic, Karen L. Oliver   +5 more
wiley   +1 more source

A review of the equine suspensory ligament: Injury prone yet understudied

Equine Veterinary Journal, EarlyView.
Abstract The suspensory ligament (SL) is a key component of the elaborate and highly adapted suspensory apparatus in the horse. In addition to contributing to stabilisation of the metacarpophalangeal joint, the SL has a spring like function to reduce the energetic cost of locomotion.
Deborah J. Guest, Helen L. Birch, Chavaunne T. Thorpe   +2 more
wiley   +1 more source

A genome‐wide association study for recurrent laryngeal neuropathy in the Thoroughbred horse identifies a candidate gene that regulates myelin structure

Equine Veterinary Journal, EarlyView.
Abstract Background Equine recurrent laryngeal neuropathy (RLN) is an economically important upper respiratory tract (URT) disease with a genetic contribution to risk, but genetic variants independent of height have not been identified for Thoroughbreds.
Charlotte L. McGivney, Beatrice A. McGivney, Gabriella Farries, Katie F. Gough, Haige Han, Amy R. Holtby, David E. MacHugh, Lisa Michelle Katz, Emmeline W. Hill   +8 more
wiley   +1 more source