Results 331 to 340 of about 2,929,620 (353)
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Current Protocols, 2021
AbstractAs genome‐wide association studies have continued to identify loci associated with complex traits, the implications of and necessity for proper use of these findings, including prediction of disease risk, have become apparent. Many complex diseases have numerous associated loci with detectable effects implicating risk for or protection from ...
Tyler G. Kinzy +2 more
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AbstractAs genome‐wide association studies have continued to identify loci associated with complex traits, the implications of and necessity for proper use of these findings, including prediction of disease risk, have become apparent. Many complex diseases have numerous associated loci with detectable effects implicating risk for or protection from ...
Tyler G. Kinzy +2 more
openaire +3 more sources
Polygenic scores in biomedical research
Nature Reviews Genetics, 2022Public health strategies aimed at disease prevention or early detection and intervention have the potential to advance human health worldwide. However, their success depends on the identification of risk factors that underlie disease burden in the general population.
Iftikhar J. Kullo +5 more
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Journal of the American Medical Association (JAMA), 2023
Importance Coronary artery calcium score and polygenic risk score have each separately been proposed as novel markers to identify risk of coronary heart disease (CHD), but no prior studies have directly compared these markers in the same cohorts ...
S. Khan +17 more
semanticscholar +1 more source
Importance Coronary artery calcium score and polygenic risk score have each separately been proposed as novel markers to identify risk of coronary heart disease (CHD), but no prior studies have directly compared these markers in the same cohorts ...
S. Khan +17 more
semanticscholar +1 more source
Polygenic Scores for ADHD: A Meta-Analysis
Research on Child and Adolescent Psychopathology, 2021Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder that is known to have a polygenic (i.e., many genes of individually small effects) architecture. Polygenic scores (PGS), which characterize this polygenicity as a single score for a given individual, are considered the state-of-the-art in psychiatric ...
James J. Li, Quanfa He
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Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention.
JAMA cardiology, 2022Importance The clinical utility of polygenic risk scores (PRS) for coronary artery disease (CAD) has not yet been established. Objective To investigate the ability of a CAD PRS to potentially guide statin initiation in primary prevention after ...
N. Marston +15 more
semanticscholar +1 more source
Polygenic risk score in prostate cancer
Current Opinion in Urology, 2022Purpose of review This study was conducted in order to review the outcomes regarding polygenic risk score (PRS) in prediction of prostate cancer (PCa). With the increasing proficiency of genetic analysis, assessment of PRS for prediction of PCa has been performed in numerous studies.
Jong Jin, Oh, Sung Kyu, Hong
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Polygenic risk scores in coronary artery disease
Current Opinion in Cardiology, 2022Purpose of review Recent advances in genetics have facilitated the calculation of polygenic risk scores (PRSs) based on common genetic risk variants of coronary artery disease (CAD). Here, we provide an explanation of the genetic basis for PRSs and review recent literature investigating PRSs and the clinical utility for ...
Christiansen, Morten Krogh +2 more
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Taking a lifespan approach to polygenic scores
Behavioral and Brain Sciences, 2023Abstract This commentary is a call to action for researchers to create and use genome-wide association studies (GWASs) with previously missed age groups (e.g., infancy, elderly), which will improve our ability to ask important developmental questions using genetic data to trace pathways across the lifespan.
Eloise W. Freitag, Caroline M. Kelsey
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2022
Coronary artery disease (CAD) is highly heritable. The technological advances over the past decade have enabled faster and more comprehensive genetic analysis with a simultaneous lowering of costs. This has resulted in a better understanding of the genetic determinants of atherosclerosis and CAD, and thus an increasing interest in and demand for ...
Christoffersen, Mette +1 more
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Coronary artery disease (CAD) is highly heritable. The technological advances over the past decade have enabled faster and more comprehensive genetic analysis with a simultaneous lowering of costs. This has resulted in a better understanding of the genetic determinants of atherosclerosis and CAD, and thus an increasing interest in and demand for ...
Christoffersen, Mette +1 more
openaire +2 more sources
Seminars in Arthritis and Rheumatism
Polygenic risk scores (PRS) estimate an individual's genetic risk for a disease or trait compared to a matched population. For many rheumatic diseases PRS have been developed that have discriminatory capacity better than some widely used biomarkers, and in some cases are the most discriminatory tests available.
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Polygenic risk scores (PRS) estimate an individual's genetic risk for a disease or trait compared to a matched population. For many rheumatic diseases PRS have been developed that have discriminatory capacity better than some widely used biomarkers, and in some cases are the most discriminatory tests available.
openaire +2 more sources