Results 61 to 70 of about 448,187 (305)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

The thermo-mechanical performance of glass-fibre reinforced Polyamide 66 during glycol-water hydrolysis conditioning [PDF]

open access: yes, 2010
Injection moulded glass-fibre reinforced polyamide 66 composites based on two glass fibre products with different sizing formulations and unreinforced polymer samples have been characterised by dynamic mechanical analysis and unnotched Charpy impact ...
Ali, J.Z., Anderson, J., Thomason, J.L.
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Mechanically whipped phenolic froths as versatile templates for manufacturing phenolic and carbon foams

open access: yesMaterials & Design, 2019
Stable, liquid phenolic froths have been produced by whipping air into a mixture of phenolic resole, catalyst and surfactant. These liquid froths can be moulded into desired shapes and cured to produce open porous phenolic foams.
Mohammad Jalalian   +5 more
doaj   +1 more source

Large energy soliton erbium-doped fiber laser with a graphene-polymer composite mode locker

open access: yes, 2009
Due to its unique electronic property and the Pauli Blocking Principle, atomic layer graphene possesses wavelength-independent ultrafast saturable absorption, which can be exploited for the ultrafast photonics application.
Bao, Qiaoliang   +4 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

A theoretical and experimental investigation into multilayered piezoelectric composite transducers [PDF]

open access: yes, 2002
The behaviour of a number of 3-1 connectivity piezoelectric composite plate transducers is presented. The fundamental thickness mode resonance of such devices is found to be contaminated by lateral resonant activity; this is evidenced in the measured and
Hayward, G., O'Leary, R.L.
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

On the interest of using degradable fillers in co-ground composite materials [PDF]

open access: yes, 2009
The article presents the results of a study whose objective is to show the interest of using vegetable and biodegradable fillers in composite materials.
Le Bolay, Nadine   +2 more
core   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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