Results 41 to 50 of about 6,053,022 (338)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Electrostatic interaction regulated self-assembly of simple inorganic macroions into blackberry structures and their possible role as compartment systems in the origin of life

Giant, 2022
Blackberry structure is a type of universal, stable, porous, single layered, hollow, spherical supramolecular structure with sizes from tens to hundreds of nanometers self-assembled by various macroions (1–6 nm-size) in dilute solutions of water or other
Ehsan Raee, Xinyu Sun, Yuqing Yang, Xiaohan Xu, Yifan Zhou, Nita Sahai, Tianbo Liu   +6 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Chloroplast‐inspired Scaffold for Infected Bone Defect Therapy: Towards Stable Photothermal Properties and Self‐Defensive Functionality

Advanced Science, 2022
Bone implant‐associated infections induced by bacteria frequently result in repair failure and threaten the health of patients. Although black phosphorus (BP) material with superior photothermal conversion ability is booming in the treatment of bone ...
Yao Zhao, Xu Peng, Dingqian Wang, Hongbo Zhang, Qiangwei Xin, Mingzhen Wu, Xiaoyang Xu, Fan Sun, Zeyuan Xing, Luning Wang, Peng Yu, Jing Xie, Jiehua Li, Hong Tan, Chunmei Ding, Jianshu Li   +15 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Analysis of automotive liftgate seals using finite element analysis

Polímeros, 2010
Seals have wide application in automotive products. They are responsible for sealing the car in several parts such as the doors, the air intake cowl seal, and air intake lights seal. Strain and stress studies are very important in order to understand the
Rafael H. T Ueda, Lincoln C Brandão, Carlos H Lauro   +2 more
doaj  

Fabrication of helix–fiber composites with mechanically coupled core-wrapping for programmable properties

Communications Materials, 2023
Helix-fiber composites (HFCs), which involve wrapping a material around a flexible core, are of interest for intelligent stretchable functional materials or devices.
Dan Li, Zhiwei Zhu, Ziyu Zhao, Yuan Ji, Xuewei Fu, Zunfeng Liu, Wei Yang, Yu Wang   +7 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Hybrid Science‐Guided Machine Learning Approach for Modeling Chemical and Polymer Processes [PDF]

, 2023
Y. A. Liu, Niket Sharma
openalex   +1 more source

A negative piezo-conductive effect from doped semiconducting polymer thin films

Scientific Reports, 2021
In the past years, piezo-conductive sensors have drawn great attention in both academic and industrial sectors. The piezo-conductive sensors made by inorganic semiconductors exhibited poor mechanical flexibility, restricting their further practical ...
Chao Yi, Lening Shen, Jie Zheng, Xiong Gong   +3 more
doaj   +1 more source