Results 91 to 100 of about 835,152 (295)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

A Numerical–Experimental Approach for Multi‐Matrix Fiber‐Reinforced Plastics Characterization Using Finite Element Model Updating

Advanced Engineering Materials, EarlyView.
A numerical–experimental framework is developed for characterizing multi‐matrix fiber‐reinforced polymers (MM‐FRPs) combining epoxy and polyurethane matrices. Harmonic bending tests are integrated with finite element model updating (FEMU) to simultaneously identify elastic and viscoelastic material parameters.
Rodrigo M. Dartora, Tales V. Lisbôa, Axel Spickenheuer, Rogério J. Marczak, Jakson M. Vassoler   +4 more
wiley   +1 more source

Green Synthesis of Silver Nanoparticles and Polymeric Nanofiber Composites: Fabrications, Mechanisms, and Applications

This manuscript reviews the green synthesis of silver nanoparticles (AgNPs) and their incorporation into polymeric nanofiber composites. It discusses various synthesis methods, emphasizing eco-friendly biological approaches over chemical and physical ...
Abdulrahman Mohammed Alhudhaibi, Bendif, Hamdi, Tarek H. Taha, Taha, Tarek H., Afifi, Feras M., Sulaiman A. Alsalamah, Faqihi, Abdullah A., Abdullah A. Faqihi, Alhudhaibi, Abdulrahman Mohammed, Hany M. Abdelmoneim, Alsalamah, Sulaiman A., Hamdi Bendif, Abdelmoneim, Hany M., Feras M. Afifi   +13 more
core   +1 more source

A Simplified Laminar Flow Model for the Pultrusion of Glass Fiber/Polyethylene Terephthalate Commingled Yarns

Advanced Engineering Materials, EarlyView.
A simplified thermoplastic pultrusion model is developed to predict thermal fields in glass fiber/polyethylene terephthalate (GF/PET) composites with reduced computational cost. By combining effective material homogenization, validation against literature data, and Gaussian‐process‐based optimization, the study reveals how heating limits, pulling speed,
Elder Soares, Nadège Bouchonneau, Christian Jochum, Donald Radford   +3 more
wiley   +1 more source

Flexural Behavior of 3D‐Printed Porous Bouligand‐Structured Polymers: Influence of Pitch Angle and Porosity

Advanced Engineering Materials, EarlyView.
This study examines how helicoidal architectures with different porosities respond to bending. Adjusting layer angle and spacing in 3D‐printed polymers reveals clear tradeoffs between stiffness, strength, and energy absorption. Experiments and simulations highlight designs that distribute stress effectively, offering pathways for optimizing lightweight
Praveenkumar Subhash Patil, Edward D. McCarthy, Parvez Alam   +2 more
wiley   +1 more source

Soft Plastic Robots and Artificial Muscles

International Journal of Advanced Robotic Systems, 2008
Ionic polymeric materials suitably made into a functionally-graded composite with a conductor such as a metal, graphite or synthetic metal such as conductive polymers that act as a distributed electrode can exhibit large dynamic deformation if placed in ...
Mohsen Shahinpoor
doaj  

Bioactive Polymeric Materials for Tissue Repair

Journal of Functional Biomaterials, 2017
Bioactive polymeric materials based on calcium phosphates have tremendous appeal for hard tissue repair because of their well-documented biocompatibility. Amorphous calcium phosphate (ACP)-based ones additionally protect against unwanted demineralization
Diane R. Bienek, Wojtek Tutak, Drago Skrtic   +2 more
doaj   +1 more source

Comparison of Triply Periodic Minimal Surface Energy Absorbers Under Uniaxial Compressive Loading

Advanced Engineering Materials, EarlyView.
This study investigates LCD 3D printed Triply Periodic Minimal Surface (TPMS) structures as mechanical energy absorbers. By comparing various base designs and layered combinations under uniaxial compression, it identifies that a Diamond‐Gyroid sandwich structure offers superior performance.
Sergej Grednev, Noah‐Lean Roschlaub, Anne Jung   +2 more
wiley   +1 more source

Cannabidiol-loaded microparticles embedded in a porous hydrogel matrix for biomedical applications

Journal of Materials Science: Materials in Medicine
In this study, poly (lactic-co-glycolic acid) (PLGA) microparticles loaded with cannabidiol (CBD) were synthesized (PLGA@CBD microparticles) and embedded up to 10 wt% in a chondroitin sulfate/polyvinyl alcohol hydrogel matrix. In vitro chemical, physical,
Carla David, Jaqueline F. de Souza, Adriana F. Silva, Guillermo Grazioli, Andressa S. Barboza, Rafael G. Lund, André R. Fajardo, Rafael R. Moraes   +7 more
doaj   +1 more source

Employing Metal-Enriched Polymeric Composites: An Innovative Approach for Combatting Microbes and Bacteria in Building Components in Public Places

Buildings
The escalating occurrence of hospital-associated infections globally, compounded by the ongoing pandemic, has spurred researchers to delve into innovative approaches for combating pathogens and overcoming their resistance to commonly used materials.
Aaruci Agarwalla, Waleed Ahmed, Ali H. Al-Marzouqi, Tahir A. Rizvi, Essam Zaneldin, Mushtaq Khan   +5 more
doaj   +1 more source