Results 51 to 60 of about 472,520 (303)

Leakage current and surface discharge phenomena : effect on tracking and morphological properties of LLDPE-natural rubber compounds [PDF]

open access: yes, 2003
Polymeric insulators are widely used for high voltage outdoor insulating application due to their substantial advantages compared to the porcelain and glass insulators.
Darus, Ahmad, Hassan, A., Piah, M. A. M.
core  

Viscoelastically prestressed polymeric matrix composites: An overview [PDF]

open access: yes, 2016
Elastically prestressed polymeric matrix composites exploit the principles of prestressed concrete, i.e. fibres are stretched elastically during matrix curing.
Fancey, Kevin S.
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Engineered polylactide (PLA)–polyamide (PA) blends for durable applications: 1. PLA with high crystallization ability to tune up the properties of PLA/PA12 blends

open access: yesEuropean Journal of Materials, 2022
Polylactide (PLA), a biodegradable polyester produced from renewable resources, has a key position in the very promising market for bioplastics. Unfortunately, for utilization in durable/engineering applications, PLA suffers from some shortcomings such ...
Marius Murariu   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

Acid-resistant chemotactic DNA micromotors for probiotic delivery in inflammatory bowel disease

open access: yesNature Communications
Microcapsules composed of synthetic polymeric matrices have attracted considerable attention in delivering oral probiotics. However, existing polymeric microcapsules demonstrate inadequate acid resistance and adaptability, as well as deficiency in the ...
Zinan Zhao, Yao Xu, Yong Hu
doaj   +1 more source

Nanomedicine‐boosting icaritin-based immunotherapy of advanced hepatocellular carcinoma

open access: yesMilitary Medical Research, 2022
Traditional treatments for advanced hepatocellular carcinoma (HCC), such as surgical resection, transplantation, radiofrequency ablation, and chemotherapy are unsatisfactory, and therefore the exploration of powerful therapeutic strategies is urgently ...
Yi Lu   +4 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Computational homogenization of fibrous piezoelectric materials [PDF]

open access: yes, 2015
Flexible piezoelectric devices made of polymeric materials are widely used for micro- and nano-electro-mechanical systems. In particular, numerous recent applications concern energy harvesting.
De Lorenzis, Laura   +3 more
core   +1 more source

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