Results 161 to 170 of about 8,907,599 (231)

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Synthesis of the dumbbell AuNRs@BCP nanoparticles <i>via</i> UV light-initiated RAFT polymerization-induced self-assembly. [PDF]

RSC Adv
Wang J, Xu F, Liu Z, Xu L, Liu M, Deng Y, Sun Y, Zhang Y, Wang DH, Huang Y.   +9 more
europepmc   +1 more source

Using Polymerization-Induced Self-Assembly in Orthogonally-Reactive Dispersants to Design Tough Nanostructured Materials: Application to Epoxy Networks. [PDF]

Angew Chem Int Ed Engl
Ienn T, Lo Van C, Brunel R, Albertini D, Chamczyk E, Alcouffe P, Sudre G, Lortie F, Bernard J.   +8 more
europepmc   +1 more source

Photovoltaic Stimulation of Mouse and Pig Retina With Pyrolytic Carbon Microelectrodes Integrated on High‐Density Silicon Solar Cell Arrays

Advanced Healthcare Materials, EarlyView.
In this study, we fabricate photovoltaic retinal implants with pyrolytic carbon electrodes and test their ability to stimulate mouse and pig retinas when illuminated with near‐infrared light. We find increased spiking activity in both animal models compared to spontaneous activity and TTX controls and analyze the spike amplitude, latency and frequency.
Akihiro Matsumoto, Pratik Kusumanchi, Jesper Guldsmed Madsen, Asbjørn Cortnum Jørgensen, Gisele Alves dos Reis Benatto, Sune Thorsteinsson, Peter Behrensdorff Poulsen, Keisuke Yonehara, Toke Bek, Stephan Sylvest Keller, Rasmus Schmidt Davidsen   +10 more
wiley   +1 more source

Synthesis of Poly(δ-valerolactone)-poly(<i>N,N</i>-dimethylacrylamide) Supermicelles in Concentrated Aqueous Media via Reverse Sequence Polymerization-Induced Self-Assembly. [PDF]

Macromolecules
Farmer MAH, Mykhaylyk OO, Musa OM, Armes SP.   +3 more
europepmc   +1 more source

Correction to "Continuous-Flow Laboratory SAXS for In Situ Determination of the Impact of Hydrophilic Block Length on Spherical Nano-Object Formation during Polymerization-Induced Self-Assembly". [PDF]

Macromolecules, 2023
Guild JD, Knox ST, Burholt SB, Hilton EM, Terrill NJ, Schroeder SLM, Warren NJ.   +6 more
europepmc   +1 more source

Hydrophilic Polymers Enable Gastrointestinal Transit Monitoring by Fluorine‐19 Magnetic Resonance Imaging

Advanced Healthcare Materials, EarlyView.
Hydrophilic fluorinated copolymers dissolve in chyme and give a strong, single 19F signal, unlike phase‐separating perfluorocarbons. Combined 1H‐19F MRI tracks their whole‐gut transit non‐invasively and without ionizing radiation. In rats, the tracers move through the gastrointestinal tract, resist resorption, and are well tolerated, a proof‐of‐concept
Ondřej Groborz, Vít Herynek, Mária Hovořáková, Zuzana Pavlíková, Linda Dalecká, Klára Steklíková, Petr Matouš, Petr Páral, Margarita Tkachenko, Filip Koucký, Fatma Nalan Cetin, Ludmila Maffei Svobodová, Jiří Beneš, Kristýna Kolouchová   +13 more
wiley   +1 more source

pH-Responsive polymeric vesicles prepared <i>via</i> polymerization-induced self-assembly for controlled 5-fluorouracil delivery. [PDF]

RSC Adv
Alhaidari LM, Altariqi R, Alkhamis T, Alanezi R, Merghani NM.   +4 more
europepmc   +1 more source

Continuous-Flow Laboratory SAXS for In Situ Determination of the Impact of Hydrophilic Block Length on Spherical Nano-Object Formation during Polymerization-Induced Self-Assembly. [PDF]

Macromolecules, 2023
Guild JD, Knox ST, Burholt SB, Hilton EM, Terrill NJ, Schroeder SLM, Warren NJ.   +6 more
europepmc   +1 more source