Results 101 to 110 of about 823,472 (307)

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Highly scalable, dialysis-controlled synthesis of colloidal molecules via regulated self-assembly of polymer-grafted gold nanoparticles

Nature Communications
Colloidal molecules (CMs) are assemblies of nanoparticles (NPs) that accurately replicate the structure and symmetry of actual molecules. Regarded as modular building blocks, CMs enable the creation of hierarchical structures that are challenging to ...
Huibin He, Chongyang Yao, Xiaoxue Shen, Jing Tao, Di Zheng, Liwei Dai, Runshi Qiao, Yutao Sang, Zhihong Nie   +8 more
doaj   +1 more source

Naturapolyceutics: The Science of Utilizing Natural Polymers for Drug Delivery

, 2014
Naturapolyceutics defines the emerging science and technology platform that blends natural polymers and pharmaceutics for the design and development of drug delivery systems.
Nelson Ochekpe, Okezie Aruoma, Ndidi Ngwuluka   +2 more
core   +1 more source

Engineering Polymer Informatics: Towards the Computer‐Aided Design of Polymers [PDF]

, 2008
The computer‐aided design of polymers is one of the holy grails of modern chemical informatics and of significant interest for a number of communities in polymer science.
Nico Adams, Peter Murray-Rust, Adams, Nico, Murray-Rust, Peter   +3 more
core   +2 more sources

A Numerical–Experimental Approach for Multi‐Matrix Fiber‐Reinforced Plastics Characterization Using Finite Element Model Updating

Advanced Engineering Materials, EarlyView.
A numerical–experimental framework is developed for characterizing multi‐matrix fiber‐reinforced polymers (MM‐FRPs) combining epoxy and polyurethane matrices. Harmonic bending tests are integrated with finite element model updating (FEMU) to simultaneously identify elastic and viscoelastic material parameters.
Rodrigo M. Dartora, Tales V. Lisbôa, Axel Spickenheuer, Rogério J. Marczak, Jakson M. Vassoler   +4 more
wiley   +1 more source

Using thermokinetic methods to enhance properties of epoxy resins with amino acids as biobased curing agents by achieving full crosslinking

Scientific Reports
Fibre-reinforced polymers (FRPs) are used in numerous industrial sectors and contribute to reducing CO2 emissions due to their outstanding properties in lightweight design.
Melissa Walter, Marcel Neubacher, Bodo Fiedler   +2 more
doaj   +1 more source

A Simplified Laminar Flow Model for the Pultrusion of Glass Fiber/Polyethylene Terephthalate Commingled Yarns

Advanced Engineering Materials, EarlyView.
A simplified thermoplastic pultrusion model is developed to predict thermal fields in glass fiber/polyethylene terephthalate (GF/PET) composites with reduced computational cost. By combining effective material homogenization, validation against literature data, and Gaussian‐process‐based optimization, the study reveals how heating limits, pulling speed,
Elder Soares, Nadège Bouchonneau, Christian Jochum, Donald Radford   +3 more
wiley   +1 more source

Rheological, mechanical, and cytotoxic properties of sustainable NR/glass fiber composites: prospects for advanced applications

BMC Chemistry
Glass fiber is an inorganic reinforcement material widely used in rubber-based technological products. This study investigates the properties of natural rubber/glass fiber composites, focusing on their potential to enhance mechanical performance while ...
Doaa S. Mahmoud, Abdelmohsen M. Soliman, Fahima M. Helaly, Salwa H. El-Sabbagh   +3 more
doaj   +1 more source