Results 151 to 160 of about 3,200,406 (285)

Current status of liver transplantation for non‐B non‐C liver cirrhosis and hepatocellular carcinoma

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 42-52, January 2023., 2023
Recently, the cases of LT for non‐B non‐C cirrhosis and HCC have been increasing in Japan as well as worldwide. Perioperative management of non‐B non‐C liver disease is problematic due to various risk factors, including alcohol consumption and metabolic syndrome‐related risks, such as obesity and diabetes mellitus.
Takahiro Nishio, Takashi Ito, Koichiro Hata, Kojiro Taura, Etsuro Hatano   +4 more
wiley   +1 more source

NF2 is Essential for Human Endoderm Development

Advanced Science, EarlyView.
This study demonstrates that NF2, moesin‐ezrin‐radixin like (MERLIN) tumor suppressor (NF2) is essential for human endoderm formation. NF2 knockout human induced pluripotent stem cells fail to form endoderm both in vitro and in vivo due to yes‐associated protein 1 (YAP1) nuclear translocation, redirecting differentiation toward myofibroblast‐like cells.
Minjin Jeong, Dongjun Han, Preetida Bhetariya, D. Bradley Welling, Miodrag Stojkovic, Konstantina M. Stankovic   +5 more
wiley   +1 more source

Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism

Nature, 2015
D. Oldridge, A. Wood, Nina Weichert-Leahey, Ian Crimmins, Robyn T. Sussman, C. Winter, L. McDaniel, M. Diamond, Lori S. Hart, Shizhen Zhu, Adam D. Durbin, B. Abraham, L. Anders, Lifeng Tian, Shile Zhang, Jun S. Wei, J. Khan, K. Bramlett, N. Rahman, M. Capasso, A. Iolascon, D. Gerhard, J. G. Auvil, R. Young, H. Hakonarson, S. Diskin, A. Look, J. Maris   +27 more
semanticscholar   +1 more source

Controllable Crystalline Phases of Multi‐Cation Oxides

Advanced Science, EarlyView.
This work demonstrates the control of crystal phases in rare‐earth titanates containing multiple rare‐earth elements. By combining atomic‐level structure characterization techniques, the atomic structures are elucidated, and entropy of mixing for each phase is quantitatively estimated.
Takafumi Ogawa, Makoto Tanaka, Naoki Kawashima, Taishi Ito, Kei Nakayama, Takeharu Kato, Satoshi Kitaoka   +6 more
wiley   +1 more source

Leveraging Automated Machine Learning for Environmental Data‐Driven Genetic Analysis and Genomic Prediction in Maize Hybrids

Advanced Science, EarlyView.
An automated machine learning framework integrating environmental and genomic data enhances genetic analysis and genomic prediction in maize. By leveraging dimension‐reduced environmental parameters, it reveals trait‐environment relationships and identifies genetic markers that govern phenotypic plasticity and genotype‐by‐environment interactions.
Kunhui He, Tingxi Yu, Shang Gao, Shoukun Chen, Liang Li, Xuecai Zhang, Changling Huang, Yunbi Xu, Jiankang Wang, Boddupalli M. Prasanna, Sarah Hearne, Xinhai Li, Huihui Li   +12 more
wiley   +1 more source

The Super Enhancer‐Driven Long Noncoding RNA PRKCQ‐AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule Compounds

Advanced Science, EarlyView.
PRKCQ‐AS1 is overexpressed due to transcriptional super‐enhancers. PRKCQ‐AS1 RNA forms a complex with MSI2 protein to induce BMX mRNA stabilization and overexpression, ERK protein phosphorylation and neuroblastoma cell proliferation. Compound NSC617570 blocks PRKCQ‐AS1 binding to MSI2, leading to BMX mRNA disassociation from MSI2 protein, BMX reduction,
Sujanna Mondal, Pei Y. Liu, Janith Seneviratne, Antoine De Weck, Pooja Venkat, Chelsea Mayoh, Jing Wu, Jesper Maag, Jingwei Chen, Matthew Wong, Nenad Bartonicek, Poh Khoo, Lei Jin, Louise E. Ludlow, David S. Ziegler, Toby Trahair, Pieter Mestdagh, Belamy B. Cheung, Jinyan Li, Marcel E. Dinger, Ian Street, Xu D. Zhang, Glenn M. Marshall, Tao Liu   +23 more
wiley   +1 more source

Digital droplet PCR versus quantitative PCR for lipoprotein (a) kringle IV type 2 repeat polymorphism genetic characterization. [PDF]

J Clin Lab Anal
Barbieri G, Cassioli G, Kura A, Orsi R, Magi A, Berteotti M, Scaturro GM, Lotti E, Gori AM, Marcucci R, Giusti B, Sticchi E.   +11 more
europepmc   +1 more source

Cubic Phase‐Inducible Zwitterionic Phospholipids Improve the Functional Delivery of mRNA

Advanced Science, EarlyView.
In this study, a chemically engineered zwitterionic phospholipids derived from 1,2‐dioleoyl‐3‐sn‐glycero‐phosphoethanolamine (DOPE), DOPE‐Cx, are designed. The DOPE‐Cx lipids induce a cubic phase upon mixing with phosphatidylcholine, facilitate membrane fusion‐mediated endosomal escape, and enhance the functional delivery of mRNA.
Kazuki Iwakawa, Rikako Sato, Mariko Konaka, Yuma Yamada, Hideyoshi Harashima, Yusuke Sato   +5 more
wiley   +1 more source

The Rise of Chalcohalide Solar Cells: Comprehensive Insights From Materials to Devices

Advanced Science, EarlyView.
This review provides a detailed overview of recent advancements in chalcohalide solar cells, focusing on structure design, material chemistry, synthesis methods, and device optimization. It also highlights future directions for improving device efficiency through innovative device architectures and synthesis techniques, addressing key challenges in ...
Hongrui Zhang, Yiming Xia, Yangfan Zhang, Uma V. Ghorpade, Mingrui He, Seung Wook Shin, Xiaojing Hao, Mahesh P. Suryawanshi   +7 more
wiley   +1 more source

Cutaneous T‐cell lymphomas: 2023 update on diagnosis, risk‐stratification, and management

American Journal of Hematology, Volume 98, Issue 1, Page 193-209, January 2023., 2023
Abstract Disease Overview Cutaneous T‐cell lymphomas are a heterogenous group of T‐cell neoplasms involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS). Diagnosis The diagnosis of MF or SS requires the integration of clinical and histopathologic data.
Alexandra C. Hristov, Trilokraj Tejasvi, Ryan A. Wilcox   +2 more
wiley   +1 more source