Results 41 to 50 of about 19,674 (236)

Implication of alterations in Parkin gene among North Indian patients with colorectal cancer

The Turkish Journal of Gastroenterology, 2020
Background/Aims: Alterations in Parkin (PRKN) have been described in many cancers; however, the molecular mechanism that contributes to loss of Parkin expression in colorectal cancer (CRC) remains unclear.
Raj Ranjan Tiwari, Khushnuma Wahabi, Ahmad Perwez, Zafar Iqbal Bhat, Syed Shamimul Hasan, Sundeep Singh Saluja, Moshahid Alam Rizvi   +6 more
doaj   +1 more source

Multiparametric determination of genes and their point mutations for identification of beta-lactamases [PDF]

, 2010
More than half of all currently used antibiotics belong to the beta-lactam group, but their clinical effectiveness is severely limited by antibiotic resistance of microorganisms that are the causative agents of infectious diseases. Several mechanisms for
A. A. Medeiros, A. Bauernfield, A. J. Brookes, A. M. Egorov, A. Nikulin, A. Philippon, A. Tamilselvi, A. Yu. Rubina, B. E. E. Cleven, B. Strommenger, C. C. Randegger, C. D. Steward, C. Heritier, C. Heritier, C. I. Birkett, C. Mabilat, C. Mugnaioli, D. E. Mudrak, D. Gryadunov, D. L. Paterson, D. L. Paterson, D. L. Paterson, D. M. Leinberger, D. M. Livermore, D. M. Livermore, D. M. Livermore, D. M. Livermore, D. M. Livermore, D. Szabo, D. V. Ivanov, E. B. Chaibi, E. M. Southern, F. Hayes, F. J. L. Robberts, F. Perez, F.-H. M’Zali, G. F. Weldhagen, H. C. Maltezou, H. F. Chambers, H. J. Monstein, H. Knothe, H. Wang, I. Massova, I. Rodriguez, I. Weigand, I. Wiegand, J. D. D. Pitout, J. D. D. Pitout, J. D. Pitout, J. D. Pitout, J. Empel, J. F. Petrosino, J. L. Jones, J. M. Ghuysen, J. Rodriguez-Bano, J. Schlesinger, J. Schmitt, J. W. Schumm, K. Bush, K. Bush, K. Bush, L. Bodrossy, L. Drieux, L. N. Ikryannikova, L. Pagani, L. Poirel, L. Poirel, L. S. Tzouvelekis, L. X. Zhu, L. Xu, L. Xu, M. Babic, M. Batchelor, M. Cassone, M. Chee, M. Edelstein, M. F. Lartigue, M. Guckenberger, M. H. Richmond, M. I. Page, M. J. Heller, M. J. Schwaber, M. J. Schwaber, M. M. Ulyashova, M. M. Ulyashova, M. Nukaga, M. Ozsoz, M. Quinteros, M. R. Mulvey, M. Schena, M. Shogo, M. Yu. Rubtsova, N. C. Strynadka, N. Datta, N. Shibata, N. Woodford, N. Woodford, P. A. James, P. Bradford, P. C. Fleming, P. M. Hawkey, R. Alonso, R. B. Sykes, R. Bonnet, R. Bonnet, R. Canton, R. D. Schmid, R. P. Ambler, S. Chen, S. Egorova, S. Harada, S. K. Du Bois, S. Kalai Blagui, S. V. Sidorenko, S. V. Sidorenko, T. L. Wu, T. Naas, T. R. Hughes, T. T. Bachmann, V. A. Doss, V. Chizhikov, V. Grimm, V. M. Ensor, V. Perreten, X. Cao, X. Yu, Y. Lee, Y. Michikawa   +127 more
core   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Methylation assay by nucleotide incorporation: a quantitative assay for regional CpG methylation density

BioTechniques, 2004
Although the aberrant methylation in CpG islands is of great interest as a causative role in human malignancies, it has been very difficult to accurately determine methylation density.
Takeshi Yamamoto, Takeshi Nagasaka, Kenji Notohara, Hiromi Sasamoto, Jun Murakami, Noriaki Tanaka, Nagahide Matsubara   +6 more
doaj   +1 more source

Variation in KRTAP6-1 affects wool fibre diameter in New Zealand Romney ewes [PDF]

Archives Animal Breeding, 2019
Variation in KRTAP6-1 has been reported to affect wool fibre traits in Merino cross-breed sheep and Chinese Tan sheep, but little is known about whether these effects persist in other breeds.
W. Li, W. Li, H. Gong, H. Gong, H. Zhou, H. Zhou, H. Zhou, J. Wang, J. Wang, S. Li, S. Li, X. Liu, X. Liu, Y. Luo, Y. Luo, J. G. H. Hickford, J. G. H. Hickford   +16 more
doaj   +1 more source

Loop flexibility in human telomeric quadruplex small-molecule complexes [PDF]

, 2015
Quadruplex nucleic acids can be formed at the ends of eukaryotic chromosomes. Their formation and stabilisation by appropriate small molecules can be used as a means of inhibiting the telomere maintenance functions of telomerase in human cancer cells ...
Campbell, NH, Collie, GW, Neidle, S
core   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

Multiple Fluorescence-Based PCR-SSCP Analysis Using Internal Fluorescent Labeling of PCR Products

BioTechniques, 1996
The method to internally label PCR products with multiple colored fluorescent dyes was developed and applied to multiple fluorescence-based PCR single-stranded conformational polymorphism (MF-PCRSSCP) analysis.
H. Iwahana, M. Fujimura, Y. Takahashi, T. Iwabuchi, K. Yoshimoto, M. Itakura   +5 more
doaj   +1 more source

A survey and a molecular dynamics study on the (central) hydrophobic region of prion proteins

, 2014
Prion diseases are invariably fatal neurodegenerative diseases that affect humans and animals. Unlike most other amyloid forming neurodegenerative diseases, these can be highly infectious. Prion diseases occur in a variety of species.
Wang, Feng, Zhang, Jiapu
core   +1 more source