DNA Nanoarray for Multiplexed RNA Detection With Single‐Molecule Readout
Advanced Science, EarlyView.A carrier‐based DNA nanoarray integrates programmable nucleic acid hybridization with solid‐state nanopore readout for direct RNA detection at single‐molecule resolution. A ternary encoding system enables 27 carriers with 81 addressable sensing sites, allowing the simultaneous identification of targets spanning a wide size range, from short microRNAs ...
Yunxuan Li +12 more
wiley +1 more source
Novel mutations in the toll like receptor genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection [PDF]
, 2008 Toll like receptors play a central role in the recognition of pathogen associated molecular patterns (PAMPs). Mutations in TLR1, TLR2 and TLR4 genes may change the PAMP reorganization ability which causes altered responsiveness to the bacterial pathogens.
Ivan Mikula Jr. +6 more
core +1 more source
Mutation Analysis of CFTR Gene in 70 Iranian Cystic Fibrosis Patients
Iranian Journal of Allergy, Asthma and Immunology, 2006 Cystic fibrosis (CF) is the most common inherited disorder in Caucasian populations, with over 1400 cystic fibrosis transmembrane conductance regulator (CFTR) mutations.
Reza Alibakhshi Mahdi Zamani
doaj
Identification of the association between FABP4 gene polymorphisms and milk production traits in Sfakia sheep [PDF]
Archives Animal Breeding, 2019 The aim of this study was to estimate the effect of variation in the fatty acid binding protein 4 gene (FABP4) on milk production traits in Greek Sfakia sheep.
A. H. M. Ibrahim +4 more
doaj +1 more source
PharmVar GeneFocus: CYP1A2—Clinical Impact, Genetic Variation, and Updated Nomenclature
Clinical Pharmacology &Therapeutics, EarlyView.The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP1A2 gene. CYP1A2 plays a crucial role in the biotransformation of several commonly used drugs, including antipsychotics, antidepressants, anxiolytics, and methylxanthines.
Katalin Monostory +13 more
wiley +1 more source
Revista Peruana de Medicina Experimental y Salud Pública, 2004 Aedes aegypti es el vector responsable de la transmisión del virus del dengue, su distribución geográfica se ha ampliado rápidamente debido principalmente a la intervención de los seres humanos.
Nélida Leiva G, Omar Cáceres R
doaj
Role of dynamic capsomere supply for viral capsid self-assembly
, 2015 Many viruses rely on the self-assembly of their capsids to protect and transport their genomic material. For many viral systems, in particular for human viruses like hepatitis B, adeno or human immunodeficiency virus, that lead to persistent infections ...
Boettcher, Marvin A. +2 more
core +1 more source
Specific loop modifications of the thrombin-binding aptamer trigger the formation of parallel structures [PDF]
, 2014 Guanine-rich sequences show large structural variability, with folds ranging from duplex to triplex and quadruplex helices. Quadruplexes are polymorphic, and can show multiple stoichiometries, parallel and antiparallel strand alignments, and different ...
Aviñó, Anna +7 more
core +1 more source
Investigation of
BMC Women's Health, 2002 Background Spontaneous premature ovarian failure presents most commonly with secondary amenorrhea. Young women with the disorder are infertile and experience the symptoms and sequelae of estrogen deficiency.
Nelson Lawrence M +4 more
doaj +1 more source
Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution [PDF]
, 2015 Activation-induced deoxycytidine deaminase (AID) generates antibody diversity in B cells by initiating somatic hypermutation (SHM) and class-switch recombination (CSR) during transcription of immunoglobulin variable (IgV) and switch region (IgS) DNA ...
Bertram, JG +7 more
core +1 more source