Results 81 to 90 of about 19,674 (236)

Overexpression of platelet-derived growth factor receptor α in breast cancer is associated with tumour progression [PDF]

, 2005
Introduction Receptor tyrosine kinases have been extensively studied owing to their frequently abnormal activation in the development and progression of human cancers.
Inês Carvalho, Fernanda Milanezi, Albino Martins, Rui M Reis, Fernando Schmitt, M Tallquist, C Betsholtz, JC Bonner, EW Raines, A Östman, MC Heinrich, S Hirota, J Kawagishi, N Weidner, MD Coltrera, D Matei, NJ Dibb, SB Hunter, JS De Jong, S Wang, Y Fernandez, A Sierra, JA Car, A Gschwind, BP Zhou, H Lassus, I Sulzbacher, DA Bronzert, H Arai, J Zhao, Y Daigo, S Carvalho, H Sihto   +32 more
core   +2 more sources

The impact of accumulating immune adaptation in circulating strains of HIV‐1

HIV Medicine, EarlyView.
Abstract Background Mutations in human immunodeficiency virus type 1 (HIV‐1) enable the virus to evade recognition and killing by human leucocyte antigen (HLA)‐restricted T cells. These viral adaptations are specific to the HLA type of individuals and are therefore evident as HLA allele‐HIV sequence associations at the population level. Most studies of
Marwah Al‐kaabi, Alison Castley, Pooja Deshpande, Abha Chopra, David Nolan, Simon Mallal, Mina John, Silvana Gaudieri   +7 more
wiley   +1 more source

The GmGT‐2F, a trihelix transcription factor, regulates seed oil content by directly activating GmAGAL transcription in soybean

Journal of Integrative Plant Biology, EarlyView.
In soybean, the trihelix transcription factor GmGT‐2F positively regulates the expression of the α‐galactosidase gene GmAGAL, thereby modulating seed oil content. The cyclophilin GmCYP2 interacts with GmGT‐2F and suppresses GmAGAL activation. Haplotype diversity analysis of GmGT‐2F, GmCYP2, and GmAGAL identified favorable haplotype combinations ...
Shuangzhe Li, Yifan Cui, Yang Liu, Mingliang Yang, Xiaoxia Wu, Qingshan Chen, Ying Zhao   +6 more
wiley   +1 more source

Identification of Ovine KRTAP28-1 and Its Association with Wool Fibre Diameter

Animals, 2019
Keratin-associated proteins (KAPs) are a diverse group of proteins and form a matrix that cross-links keratin intermediate filaments in hair and wool fibres.
Lingrong Bai, Jing Wang, Huitong Zhou, Hua Gong, Jinzhong Tao, Jon G. H. Hickford   +5 more
doaj   +1 more source

Characterization of a K+-induced conformational switch in a human telomeric DNA oligonucleotide using 2-aminopurine fluorescence [PDF]

, 2010
Human telomeric DNA consists of tandem repeats of the DNA sequence d(GGGTTA). Oligodeoxynucletotide telomere models such as d[A(GGGTTA)(3)GGG] (Tel22) fold in a cation-dependent manner into quadruplex structures consisting of stacked G-quartets linked by
Ambrus A., Antonacci C., Ballin J. D., Ballin J. D., Bouaziz S., Burge S., Chaires J. B., Chaires J. B., Collado M., Cornell W. D., Dai J., Dai J., Dai J., Deng Y., DeSa R. J., Gampp H., Garcia De La Torre J., Gaynutdinov T. I., Gaynutdinov T. I., Gray R. D., Gray R. D., Haider S., Hall K. B., He Y., Hendler R. W., Hubbard S. J., Hud N. V., Hud N. V., Huppert J. L., Huppert J. L., Ida R., Jean J. M., Jean J. M., Jean J. M., Jean J. M., Jing N., Jing N., Kelley S. O., Kimura T., Kollman P. A., Lane A. N., Lee J. Y., Li J., Luu K. N., Marathias V. M., McEachern M. J., Menger M., Misra V. K., Monod J., O'Neill M. A., Palm W., Parkinson G. N., Patel D. J., Perez A., Pettersen E. F., Phan A. T., Phan A. T., Piotto M., Schaffitzel C., Sheardy R. D., Stivers J. T., Swain J. F., Tsai C. J., Verdun R. E., Wang Y., Wilson J. N., Wright W. E., Xu Y.   +67 more
core   +1 more source

Encapsulation of a polymer by an icosahedral virus

, 2010
The coat proteins of many viruses spontaneously form icosahedral capsids around nucleic acids or other polymers. Elucidating the role of the packaged polymer in capsid formation could promote biomedical efforts to block viral replication and enable use ...
Elrad, Oren M., Hagan, Michael F.
core   +1 more source

The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development. [PDF]

, 2015
Schistosomiasis affects millions of people in developing countries and is responsible for more than 200,000 deaths annually. Because of toxicity and limited spectrum of activity of alternatives, there is effectively only one drug, praziquantel, available
Barnard, Andrew H, Fisher, Ethan MS, Karumudi, Bhargava, Podust, Larissa M, Thatcher, Gregory RJ, Williams, David L, Ziniel, Peter D   +6 more
core   +3 more sources

Identification and Functional Characterization of Isoflavone synthase Gene Family in Pea (Pisum sativum): The Entry Point to Pisatin Biosynthesis

Legume Science, Volume 8, Issue 2, June 2026.
ABSTRACT Isoflavone synthase (IFS), a cytochrome P450 monooxygenase of the CYP93C subfamily, catalyzes the conversion of flavanones into isoflavones, the first committed step in the biosynthesis of isoflavonoid phytoalexins. In pea (Pisum sativum L.), the phytoalexin pisatin plays a pivotal role in defense against pathogens.
Muhammad Sufyan Tahir, Kuflom Kuflu, Nishat Shayala Islam, Tim McDowell, Sangeeta Dhaubhadel   +4 more
wiley   +1 more source

Identification of a novel Arg→Cys mutation in the LDL receptor that contributes to spontaneous hypercholesterolemia in pigs

Journal of Lipid Research, 1999
We previously carried out genetic and metabolic studies in a partially inbred herd of pigs carrying cholesterol-elevating mutations. Quantitative pedigree analysis indicated that apolipoprotein (apo)B and a second major gene were responsible for the ...
Kurt A.A. Grunwald, Kathryn Schueler, Patricia J. Uelmen, Beth A. Lipton, Mary Kaiser, Kimberly Buhman, Alan D. Attie   +6 more
doaj   +1 more source

Protein design and RNA design: Perspectives

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley   +1 more source