Results 121 to 130 of about 568,935 (268)

Associations between the K232A polymorphism in the diacylglycerol-O-transferase 1 (DGAT1) gene and performance in Irish Holstein-Friesian dairy cattle

, 2010
peer-reviewedSelection based on genetic polymorphisms requires accurate quantification of the effect or association of the polymorphisms with all traits of economic importance. The objective of this study was to estimate, using progeny performance data
McCabe, Matthew, Waters, Sinead M., Kearney, J.F., Howard, Dawn J., O'Boyle, Padraig, Berry, Donagh   +5 more
core  

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Long non-coding RNA maternally expressed gene 3 (<i>MEG3</i>) rs4081134 gene polymorphism and preeclampsia risk. [PDF]

Turk J Obstet Gynecol
Saljoughi S, Dana H, Norouzi M, Ghadimi HS, Ghasemi M, Zargar M, Saravani M.   +6 more
europepmc   +1 more source

Association between CD14 rs2569190 C>T polymorphism and ischemic stroke susceptibility: a meta-analysis based on 5,277 subjects

, 2018
Yan-Qiong Wu,1,* Shi-Yan Cheng,2,* Xian-Cheng Xu,1 Wen-Cui Li3 1Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China; 2Department of Respiratory Medicine, Suizhou Central Hospital, Hubei University of Medicine,
Cheng SY, Li WC, Xu XC, Wu YQ
core  

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Single-Nucleotide Polymorphism (SNP) c.73G>A in the UBC9 (E2) SUMO Gene and Breast Cancer Risk in Polish Women. [PDF]

Cancers (Basel)
Romanowicz H, Sychowski G, Kalinowski S, Sypniewski S, Zakharin O, Zadrożny M, Łukasiewicz H, Samulak D, Smolarz B.   +8 more
europepmc   +1 more source

eQTL Meta‐Analysis Reveals Conserved and Population‐Specific Regulatory Variation Underlying Nutritional Trait Evolution and Domestication in Tomato

Advanced Science, EarlyView.
A comprehensive meta‐analysis of expression quantitative trait loci (eQTLs) across five diverse tomato populations reveals a high‐resolution atlas of transcriptional regulation and uncovers conserved and population‐specific regulatory architectures underlying fruit nutritional quality traits, including flavonoids, sugars, organic acids, carotenoids ...
Jiantao Zhao, Xin Wang, Jing Zhang, Ryan McQuinn, Je Min Lee, Itay Gonda, Ari Feder, Yimin Xu, Baike Wang, Qinghui Yu, Denise M. Tieman, Sanwen Huang, Harry Klee, James J. Giovannoni, Zhangjun Fei   +14 more
wiley   +1 more source

The type 2 deiodinase Thr92Ala polymorphism and cognitive aging: current evidence and biological context. [PDF]

Ther Adv Endocrinol Metab
Bing Y, Liu Y, Zhou Z, Li Y, Han Y, Meng G, Jiang Y.   +6 more
europepmc   +1 more source

Genetic polymorphism and chronic obstructive pulmonary disease

, 2017
Cunhua Yuan,1 De Chang,2 Guangming Lu,3 Xiaowei Deng1 1Health Medical Center, 2Department of Respiratory Medicine, General Hospital of Chinese People’s Armed Police Forces, 3Institute of Health Management, Chinese PLA General Hospital, Beijing ...
Yuan CH, Lu GM, Chang D, Deng XW
core  

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source