Results 231 to 240 of about 727,358 (304)

The polymorphism of acetohexamide

Journal of Pharmacy and Pharmacology, 1977
Ioannis Chroneos, Pamela Girgis-Takla
openaire   +3 more sources

(Apo)Lipoprotein Profiling with Multi‐Omics Analysis Identified Medium‐HDL‐Targeting PSRC1 with Therapeutic Potential for Coronary Artery Disease

Advanced Science, EarlyView.
Lipid content in medium high‐density lipoprotein (HDL) particles, particularly cholesteryl esters, is identified as causally protective of atherosclerosis, and further ASCVD. Evidence from multi‐omics layers of data consistently supports PSRC1 with therapeutic potential for coronary artery disease (CAD), but not ischemic stroke.
Yingmei Li, Sihan Wang, Ling Liu, Hao Cai, Yacan Huang, Mingjing Gao, Xiaogang Zhang, Qingqing Wu, Gaokun Qiu   +8 more
wiley   +1 more source

How Do Glycine‐Induced Bent Structures Influence Hierarchical Nanostructuring and Suprastructural Handedness in Short Peptide Assembly?

Advanced Science, EarlyView.
How does flexible and achiral glycine affect suprastructural handedness in peptide self‐assembly? A series of short peptides containing glycine is designed, and different molecular conformations caused by varying the position of glycine can lead to different hydrogen bonding patterns upon forming β‐sheets, eventually resulting in variations in their ...
Xinfeng Ju, Kai Qi, Yan Wang, Limin Zhang, Yingyu Wang, Muhan Wang, Jiqian Wang, Jun Zhang, Jian R. Lu, Hai Xu, Yurong Zhao   +10 more
wiley   +1 more source

Psychedelic Drugs in Mental Disorders: Current Clinical Scope and Deep Learning‐Based Advanced Perspectives

Advanced Science, EarlyView.
Graphic illustration showing the strategic approaches based on the currently investigated evidence of psychedelics that suggests the challenges and how to address the prescription of mental disorders. These applicable avenues may provide substantial insight into distinguishing between brain networks and psychedelics.
Sung‐Hyun Kim, Sumin Yang, Jeehye Jung, Jeonghyeon Choi, Mingon Kang, Jae‐Yeol Joo   +5 more
wiley   +1 more source

A HUMAN LIPOPROTEIN POLYMORPHISM [PDF]

, 1962
Baruch S. Blumberg, David H. Bernanke, A. C. Allison   +2 more
openalex   +1 more source

Assessment and Mitigation of CRISPR‐Cas9‐Induced Nontargeted Translocations

Advanced Science, EarlyView.
Various inverted repeat elements are dispersed throughout genomes. This study reveals that these elements can cause significant chromosomal rearrangements when CRISPR editing occurs in their proximity. The risk can be mitigated by incorporating inverted repeat‐homologous segments into the CRISPR system, which represents a promising strategy for ...
Zhiyang Hou, Qiyi Yi, Mengying Wu, Lijun Wu, Fanghua Li, Ting Wang, Po Bian   +6 more
wiley   +1 more source

2D Metalorganic Ferromagnets

Advanced Science, EarlyView.
The single‐layered 2D metalorganic coordination network Ni‐TCNE, made from Ni atoms and tetracyanoethylene molecules on a gold surface, is established as a ferromagnet with a high magnetic remanence and coercive field. Its Curie temperature is between 10 and 20 kelvin.
Egzona Isufi Neziri, Céline Hensky, Hien Quy Le, Diego Radillo Ochoa, Aleksandra Cebrat, Manfred Parschau, Karl‐Heinz Ernst, Christian Wäckerlin   +7 more
wiley   +1 more source

RAB3B Dictates mTORC1/S6 Signaling in Chordoma and Predicts Response to mTORC1‐Targeted Therapy

Advanced Science, EarlyView.
RAB3B is unveiled as a prominent oncogenic regulator in chordoma, which can block the DUSP12‐mediated dephosphorylation of p‐S6 (S235/236). The combination of RAB3B and p‐S6 indicates a good prognostic value and predicts mTORC1 inhibitors response for chordoma patients.
Jianxuan Gao, Jiali Jin, Runzhi Huang, Siqiao Wang, Sihui Song, Yu Zhang, Yongai Li, Jun Lin, Zhengyan Chang, Zongqiang Huang, Wei Sun, Huabin Yin, Dianwen Song, Jianru Xiao, Ping Wang, Tong Meng   +15 more
wiley   +1 more source

Conditions for Stable Polymorphism at an Autosomal Locus [PDF]

, 1962
J. B. S. Haldane
openalex   +1 more source

Silicon Carbide Photonic Crystal Photoelectrode

Advanced Science, EarlyView.
A 3C‐SiC photoelectrode with a slanted parabolic pore photonic crystal architecture enhances photogeneration for efficient photoelectrochemical water splitting through the remarkable light‐trapping capabilities of photonic crystal slow‐light modes.
Xiwen Zhang, Sajeev John
wiley   +1 more source