Results 301 to 310 of about 1,167,008 (357)

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source

Effects of Methylenetetrahydrofolate Reductase Polymorphism on Clinical Features of High-Risk Psychosis Before Schizophrenia. [PDF]

Psychiatry Investig
Wan L, Han X.
europepmc   +1 more source

Polymorphism [PDF]

, 2012
openaire   +2 more sources

A Novel Class of Multi‐substituted Diaryl Scaffold Derivatives Inhibit Glioblastoma Progression by Targeting CD155

Advanced Science, EarlyView.
Structural modification of clofoctol yielded a novel blood‐brain barrier‐permeable compound, B7, featuring a multi‐substituted diaryl scaffold. B7 demonstrates potent anti‐glioblastoma activity by suppressing glioblastoma stem cells proliferation, migration, and invasion through interactions with five key residues of poliovirus receptor cell adhesion ...
Yong‐jian Wang, Ting Sun, Si‐tu Xue, Zhong‐di Cai, Hong Yi, Miao Lv, Shi‐bo Kou, Rui Liu, Xiao‐zhong Peng, Zhuo‐rong Li   +9 more
wiley   +1 more source

The impact of serpinB3-PD polymorphism on the prognosis of patients with hepatocellular carcinoma. [PDF]

Transl Oncol
Guerra P, Ruvoletto M, Quarta S, Boninsegna G, Biasiolo A, Cagnin S, Angeli P, Pontisso P, Martini A.   +8 more
europepmc   +1 more source

Confinement‐Induced Metastable Supramolecular Assembly: Dynamic Built‐in Electric Field Driving Deep Mineralization of Organic Pollutants

Advanced Science, EarlyView.
Utilizing the 2D confined space of layered double hydroxide (LDH), living supramolecular assembly (LSA) are successfully prepared with smaller intermolecular distances than in crystals. The IEF enhancement value can reach 11.8 times, which induces a charge separation efficiency of 71.52%.
Xiaoqing Cao, Kaixiang Liang, Feifei Peng, Xianggui Kong, Wenying Shi   +4 more
wiley   +1 more source

The Genetic Polymorphisms of <i>NPPA</i>:rs5065 and <i>NPPB</i>:rs198389 and Intermediate Phenotypes of Heart Failure in Polish Patients. [PDF]

Int J Mol Sci
Gorący-Rosik A, Fic M, Rosik J, Lewandowska K, Safranow K, Ciechanowicz A, Gorący I.   +6 more
europepmc   +1 more source

Structure and Ionic Conductivity of Halide Solid Electrolytes Based on NaAlCl4 and Na2ZnCl4

Advanced Science, EarlyView.
A solid solution forms in the Na2ZnCl4‐type phase when Al³⁺ substitutes in the Zn²⁺ tetrahedral site; correspondingly, Na+ vacancies form in the Na1 site, allowing for Na hopping. The highest ionic conductivity reaches 1.5*10−5 S cm−1 at 25 °C at the edge of the miscibility gap.
Hao Guo, Michael Häfner, Helen Grüninger, Matteo Bianchini   +3 more
wiley   +1 more source

Exploring the Role of <i>SIRT1</i> Polymorphisms in Colorectal Cancer Risk: A Case-Control Study. [PDF]

J Clin Med
Klusek J, Lewitowicz P, Nowak-Starz G, Witczak B, Oblap R, Kozieł D, Nasierowska-Guttmejer A, Klusek J, Jóźwik A, Rogula T, Kocańda K, Głuszek S.   +11 more
europepmc   +1 more source

Vertical Phase Separation in Blended Organic Semiconducting Films and Impact on Their Electrical and Direct X‐Ray Detection Properties

Advanced Electronic Materials, EarlyView.
The composition of blends of 1,4,8,11‐tetramethyl‐6,13‐triethylsilylethynyl pentacene (TMTES) and polystyrene (PS) to be used in Organic Field‐Effect Transistors (OFETs) is optimized to achieve and enhance thin film crystallinity and a reduced charge trap density at the semiconductor/dielectric interface.
Maria Elisabetta Giglio, Elisabetta Colantoni, Ilaria Fratelli, Carme Martinez‐Domingo, Pedro Martinez‐Zaragoza, Giulia Napolitano, Enrico Campari, Paolo Branchini, Beatrice Fraboni, Laura Basiricó, Luca Tortora, Marta Mas‐Torrent   +11 more
wiley   +1 more source