Results 91 to 100 of about 828,217 (183)

Pleiotropy increases parallel selection signatures during adaptation from standing genetic variation. [PDF]

Elife
Lai WY, Hsu SK, Futschik A, Schlötterer C.   +3 more
europepmc   +2 more sources

Exploring Clinical and Imaging Differences in COVID-19: an Observational Approach to the IFITM3 rs12252 Polymorphism. [PDF]

Int J Gen Med
Mitrea A, Mitroi AF, Opariuc-Dan C, Constantin AA, Dantes E.   +4 more
europepmc   +1 more source

Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers

Advanced Science, EarlyView.
This study demonstrates that the resveratrol analogue, trans‐4,4′‐dihydroxystilbene (DHS), exhibits synergistic anti‐tumor activity with the PARP inhibitor talazoparib, inducing significant ovarian cancer cell death. The synergistic effect of this combination arises from the concurrent downregulation of homologous recombination factors and the ...
Ganesh Pai Bellare, Kshama Kundu, Papiya Dey, Krupa Thankam Philip, Nitish Chauhan, Muskan Sharma, Sankarsingh Kesharsingh Rajput, Birija Sankar Patro   +7 more
wiley   +1 more source

Genetic diversity and verification of plant material compliance of Cocoa (Theobroma cacao L.) in the Barombi-Kang Regional variety trial. [PDF]

PLoS One
Eyango NMC, Sounigo O, Fouet O, Tekeu H, Djocgoué FP, Efombagn MIB, Lanaud C.   +6 more
europepmc   +1 more source

NF2 is Essential for Human Endoderm Development

Advanced Science, EarlyView.
This study demonstrates that NF2, moesin‐ezrin‐radixin like (MERLIN) tumor suppressor (NF2) is essential for human endoderm formation. NF2 knockout human induced pluripotent stem cells fail to form endoderm both in vitro and in vivo due to yes‐associated protein 1 (YAP1) nuclear translocation, redirecting differentiation toward myofibroblast‐like cells.
Minjin Jeong, Dongjun Han, Preetida Bhetariya, D. Bradley Welling, Miodrag Stojkovic, Konstantina M. Stankovic   +5 more
wiley   +1 more source

Downy mildew resistance and genetic variability in a wild rocket germplasm collection

Agronomy Journal, Volume 114, Issue 6, Page 3083-3095, November/December 2022., 2022
Abstract One hundred accessions of a “core collection” of Diplotaxis tenuifolia (L.) DC. and Eruca spp. were screened at seedling stage for resistance to downy mildew. Accessions tested at the seedling stage were assigned to 0–6 interaction phenotypes.
Paula S. Coelho, João M. Reis, Ana L. Pereira, Aliana Vairinhos, Violeta Lopes, José M. Leitão   +5 more
wiley   +1 more source

Feature Selection for Hypertension Risk Prediction Using XGBoost on Single Nucleotide Polymorphism Data. [PDF]

Healthc Inform Res
Muflikhah L, Fatyanosa TN, Widodo N, Perdana RS, Solimun, Ratnawati H.   +5 more
europepmc   +1 more source

Controllable Crystalline Phases of Multi‐Cation Oxides

Advanced Science, EarlyView.
This work demonstrates the control of crystal phases in rare‐earth titanates containing multiple rare‐earth elements. By combining atomic‐level structure characterization techniques, the atomic structures are elucidated, and entropy of mixing for each phase is quantitatively estimated.
Takafumi Ogawa, Makoto Tanaka, Naoki Kawashima, Taishi Ito, Kei Nakayama, Takeharu Kato, Satoshi Kitaoka   +6 more
wiley   +1 more source

Identification of serum microRNAs as potential diagnostic biomarkers for detecting precancerous lesions of gastric cancer

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 63-70, January 2023., 2023
We found that microRNA‐196b‐5p was significantly upregulated in precancerous lesions and that combining it with other microRNAs increased the accuracy of detection. Since endoscopy is associated with risk, the identification of high‐risk groups for gastric cancer is expected to make it possible to clearly identify groups that should undergo endoscopy ...
Hajime Otsu, Sho Nambara, Qingjiang Hu, Yuichi Hisamatsu, Takeo Toshima, Kazuki Takeishi, Yusuke Yonemura, Takaaki Masuda, Eiji Oki, Koshi Mimori   +9 more
wiley   +1 more source

ONeSAMP 3.0: estimation of effective population size via single nucleotide polymorphism data from one population. [PDF]

G3 (Bethesda)
Hong A, Cheek RG, De Silva SN, Mukherjee K, Yooseph I, Oliva M, Heim M, W Funk C, Tallmon D, Boucher C.   +9 more
europepmc   +1 more source