Results 51 to 60 of about 1,171,405 (263)

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

Applying inspection to object-oriented software [PDF]

, 1995
The benefits of the object-oriented paradigmare widely cited. At the same time, inspection is deemed to be the most cost-effective means of detecting defects in software products.
Brooks, A., Macdonald, F., Miller, J., Roper, M., Wood, M.   +4 more
core   +1 more source

Relational parametricity for higher kinds [PDF]

, 2012
Reynolds’ notion of relational parametricity has been extremely influential and well studied for polymorphic programming languages and type theories based on System F.
Atkey, Robert
core   +2 more sources

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, Volume 599, Issue 7, Page 927-951, April 2025.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

The Complexity of Combinations of Qualitative Constraint Satisfaction Problems

, 2020
The CSP of a first-order theory $T$ is the problem of deciding for a given finite set $S$ of atomic formulas whether $T \cup S$ is satisfiable. Let $T_1$ and $T_2$ be two theories with countably infinite models and disjoint signatures.
Bodirsky, Manuel, Greiner, Johannes
core   +1 more source

Several types of types in programming languages [PDF]

, 2015
Types are an important part of any modern programming language, but we often forget that the concept of type we understand nowadays is not the same it was perceived in the sixties. Moreover, we conflate the concept of "type" in programming languages with
A Church, AC Kay, AJ Perlis, Alan J. Perlis, AN Whitehead, CAR Hoare, CAR Hoare, HB Curry, J McCarthy, JW Backus, L Cardelli, L De Mol, M Priestley, Michael J. Gordon, O-J Dahl, O-J Dahl, Per Martin-Löf, R Hindley, R Milner, S Martini   +19 more
core   +5 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

What's Decidable about (Atomic) Polymorphism [PDF]

arXiv, 2021
Due to the undecidability of most type-related properties of System F like type inhabitation or type checking, restricted polymorphic systems have been widely investigated (the most well-known being ML-polymorphism). In this paper we investigate System Fat, or atomic System F, a very weak predicative fragment of System F whose typable terms coincide ...
arxiv  

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

Molecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang, Haimei Wen, Ying Chen, Jingya Ning, Di Hu, Yujiao Dong, Chenyu Yao, Bo Yuan, Shuanying Yang   +8 more
wiley   +1 more source