Results 111 to 120 of about 6,612 (269)

The Role of Ultrasonography in the Diagnostic Evaluation of Patients with Polyneuropathy

Applied Sciences
Background: The role of ultrasonography (US) in the practical management of polyneuropathies, particularly axonal, remains unclear. The present study aimed to explore the contribution of the US examination of polyneuropathies in daily clinical practice ...
Maj Jožef, Simon Podnar
doaj   +1 more source

Connecting impairment, disability, and handicap in immune mediated polyneuropathies [PDF]

, 2003
BACKGROUND: In the World Health Organisation (WHO) International Classification of Impairments, Disabilities, and Handicaps (ICIDH), it is suggested that various levels of outcome are associated with one another.
Doorn, P.A. (Pieter) van, Samijn, J.P. (Johnny), Merkies, I.S.J. (Ingemar), Meché, F.G.A. (Frans) van der, Schmitz, P.I.M. (Paul)   +4 more
core  

Diabetic Peripheral Neuropathy May Be an Independent Risk Marker for Dementia and Cerebrovascular Disease

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Diabetic peripheral neuropathy (DPN) may be linked to central nervous system changes. This study examined if DPN is associated with an increased risk of incident dementia and cerebrovascular disease in individuals with Type 1 (T1D) and Type 2 diabetes (T2D). Materials and Methods This register‐based cohort study (1998–2020) used data from
Astrid Wiggers, Vanja Kosjerina, Malin Nilsson, Birgitte Brock, Steen Andersen, Evan L. Reynolds, Brian C. Callaghan, Eva L. Feldman, Jørgen Rungby, Christian Stevns Hansen   +9 more
wiley   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists and Incident Major Adverse Liver Outcomes in People With Type 2 Diabetes and Metabolic Dysfunction‐Associated Steatotic Liver Disease

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Treatment options for metabolic dysfunction‐associated steatotic liver disease (MASLD) are limited. While glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) and sodium‐glucose cotransporter‐2 (SGLT‐2) inhibitors improve cardiovascular outcomes, comparative effectiveness on liver‐related outcomes remains unclear.
Gregor A. Maier, Ramon A. Hofmann, Michael Roden, Wolfgang Rathmann, Oliver Kuss   +4 more
wiley   +1 more source

A new branch of mammalian vitamin B6 metabolism: AKR1C‐mediated conversion of pyridoxal to pyridoxine and 4‐pyridoxolactone

The FEBS Journal, EarlyView.
Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito, Yasuyuki Kitaura, Kyoka Iino, Kazuya Toriumi, Hyunah Noh, Naoya Ogawa, Makoto Arai, Hisashi Hemmi, Tomokazu Ito   +8 more
wiley   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

THE MOST FREQUENT TYPES OF DEMYELINATIVE CHARCOT-MARIE-TOOTH DISEASE IN SLOVENIA: A POPULATION-BASED STUDY

Zdravniški Vestnik, 2003
Background. The most common genetic defect in demyelinative type of Charcot-Marie-Tooth disease (CMT1) is dominantly inherited duplication of 17p11.2 (CMT1A).
Lea Leonardis, Janez Zidar, Borut Peterlin   +2 more
doaj  

Diphtheritic polyneuropathy

Journal of Pediatric Neurosciences, 2019
Joob, Beuy, Wiwanitkit, Viroj
openaire   +3 more sources

Clinical and neurophysiological spectrum of polyneuropathies in children

, 2022
PediatrijaVeselības aprūpePediatricsHealth CarePerifēra neiropātija ir perifēro nervu darbības traucējumi, ko izraisa izmaiņas perifēro sensoro, motoro un/vai autonomo neironu struktūrā vai funkcijā. Perifēro neiropātiju etioloģija ir daudzveidīga, taču
Laura Gribuste
core  

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source