Results 161 to 170 of about 21,327 (316)

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

open access: yesAdvanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth   +2 more
wiley   +1 more source

Expert Perspective: Diagnosis and Treatment of Castleman Disease

open access: yesArthritis &Rheumatology, Volume 78, Issue 1, Page 12-25, January 2026.
Castleman disease (CD) is a major diagnostic challenge for rheumatologists. Unicentric CD (UCD) involves one enlarged lymph node region, whereas multicentric CD (MCD) involves multiple enlarged lymph node regions. Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune‐mediated conditions.
Luke Y. C. Chen   +2 more
wiley   +1 more source

Multidimensional Assessment of Neurological Adverse Reactions Related to PD‐1 Inhibitors: A Real‐World Pharmacovigilance Study

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
This pharmacovigilance study systematically analyzed PD‐1 inhibitor–associated neurological adverse events using FAERS data from 2014 to 2024. Central nervous system toxicities, including encephalitis and brainstem encephalitis, were most prominent. Older age, female sex, specific cancer types, and combination therapies increased the risk, with most ...
Xiaofeng Hu   +12 more
wiley   +1 more source

Socioeconomic Inequalities and Type 2 Diabetes Comorbidities: A Systematic Review and Meta‐Analysis on Observational Studies

open access: yesEndocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Graphical abstract ABSTRACT Background Previous studies have reported inconsistent findings regarding the relationship between socioeconomic status (SES) inequalities and comorbidities in patients with diabetes mellitus (DM). This systematic review and meta‐analysis aims to evaluate, for the first time, the association between SES inequalities and ...
Mansour Bahardoust   +5 more
wiley   +1 more source

Effects of Aging on Pain Tolerance: A Comparative Study of Heat Pain Thresholds and Tonic Heat and Cold Stimuli

open access: yesEuropean Journal of Pain, Volume 30, Issue 1, January 2026.
ABSTRACT Introduction Aging is known to impact both pain perception and modulation. While sensory thresholds have been extensively studied, age‐related changes in pain tolerance remain less conclusive. Additionally, limited research has explored whether thermal modality differentially affects pain tolerance in older adults.
Julia Devanne, Louise Trocmet
wiley   +1 more source

Reduced Descending Itch Inhibition in Peripheral Neuropathy Patients With Chronic Pruritus

open access: yesEuropean Journal of Pain, Volume 30, Issue 1, January 2026.
ABSTRACT Background Peripheral neuropathies (PNP) cause a wide range of symptoms of which pruritus and pain are a major burden to patients. Clarifying their mechanisms will facilitate the adequate symptom management. In contrast to neuropathic pain, neuropathic pruritus has long been understudied.
Jonas Eck   +9 more
wiley   +1 more source

Response to High‐Dose Topical Capsaicin in Neuropathic Pain: Absence of Deep Pain as a Predictor of Analgesic Effect

open access: yesEuropean Journal of Pain, Volume 30, Issue 1, January 2026.
ABSTRACT Background Topical high‐dose capsaicin treatment is a recommended therapy for localised neuropathic pain with good tolerability and no identified drug interactions. However, it is not effective for every patient. So far, few parameters in patient history have been identified as predictors for response to capsaicin treatment.
Manon Sendel   +11 more
wiley   +1 more source

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