Results 191 to 200 of about 5,753 (265)

Development and application of a mechanistic model for protein A resolution of a bispecific antibody for process characterization and optimization

open access: yesBiotechnology Progress, EarlyView.
Abstract Regeneron's bispecific technology, based on a fully human IgG antibody construct, consists of two distinct heavy chains and a common light chain co‐expressed in a single cell. The co‐expression of the two distinct heavy chains, one of which contains a dipeptide substitution that ablates Protein A binding, leads to the formation of three ...
Samantha Wadsworth   +4 more
wiley   +1 more source

Modeling Lipid Vesicles' Dynamic Response to Osmotic Pressure to Quantify Small-Molecule Transport. [PDF]

open access: yesLangmuir
Boi S   +5 more
europepmc   +1 more source

Assessment of Gibbs Free Energy Calculation in PI‐Controlled Heating

open access: yesChemie Ingenieur Technik, EarlyView.
For description and control of chemical processes in lab or industry thermodynamic variable Gibbs free energy provides opportunity to compare and interpret phenomena, even on a quantitative level. In a case study for PI‐controlled heating, impacts on its limits from control delay until parameter quantization are highlighted and assessed.
Jannik Dutschke   +4 more
wiley   +1 more source

Coupled heat and mass transfer in reactive parallel‐plate flow: A perturbative Graetz model with modal symmetry and Arrhenius kinetics

open access: yesThe Canadian Journal of Chemical Engineering, EarlyView.
A perturbative Graetz model describes coupled heat and mass transfer in reactive Couette–Poiseuille flow between parallel plates. Viscous dissipation and heat of reaction produce a small temperature rise, which enhances Arrhenius reaction rates and modestly accelerates axial species conversion in the small‐Brinkman‐number regime.
Leonardo Damián Soria Rodríguez   +1 more
wiley   +1 more source

Z‐residuals diagnostics for Cox models: Functional‐form misspecification versus nonproportional hazards

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract Primary biliary cholangitis (PBC) is a progressive autoimmune cholestatic disease for which modelling death, with transplantation as a competing event, is clinically important. Cox proportional hazards (PH) models are widely used, but standard diagnostics detect lack of fit without distinguishing non‐PH from misspecified covariate functions ...
Tingxuan Wu, Cindy Feng, Longhai Li
wiley   +1 more source

Planar Coulomb Gas on a Jordan Arc at Any Temperature

open access: yesCommunications on Pure and Applied Mathematics, EarlyView.
ABSTRACT We study a planar Coulomb gas confined to a sufficiently smooth Jordan arc γ$\gamma$ in the complex plane, at inverse temperature β>0$\beta > 0$. Let Z¯nβ(γ)=Znβ(γ)((2cap(γ))βn2/2e(1−β/2)n(H(νe,γ)−H(νe,I)),$$\begin{equation*} \bar{Z}_{n}^\beta (\gamma)=\frac{Z_n^\beta (\gamma)}{((2\text{cap}(\gamma))^{\beta n^2/2}e^{(1-\beta /2)n(H(\nu _{e ...
K. Courteaut, K. Johansson, F. Viklund
wiley   +1 more source

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