Results 141 to 150 of about 3,855 (167)

Ocular Manifestations of PNPT1-Related Neuropathy.

Journal of neuro-ophthalmology, 2020
I nherited optic neuropathies are genetically heterogeneous often arising due to mitochondrial dysfunction with an estimated prevalence of 1 in 10,000 (1).
H. Kuht, K. Thomas, Michael Hisaund, Gail D E Maconachie, Mervyn G. Thomas   +4 more
semanticscholar   +1 more source

Structural and biochemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1

Scientific Reports, 2016
The exceptionally conserved metazoan MAB21 proteins are implicated in cell fate decisions and share considerable sequence homology with the cyclic GMP-AMP synthase.
Carina C De Oliveira Mann, Gregor Witte, Karl-peter Hopfner   +2 more
exaly   +2 more sources

Abstract 1956: miR-181d degradation mediated genetic heterogeneity and acquired resistance

Experimental and Molecular Therapeutics, 2018
When unrepaired, alkylated DNA can induce cell death or trigger mutagenesis. Cellular capacity for repair of these lesions by O 6 -methylguanine methyltransferase (MGMT) dictates the equilibrium between cell viability and genetic diversity.
Valya Ramakrishnan, J. Akers, Thien Nguyen, Aaron S. Wang, Bandita Adhikari, B. Hirshman, Jie Li, J. Sarkaria, W. Hua, Mao Ying, M. Nitta, T. Jiang, B. Carter, Clark C. Chen   +13 more
semanticscholar   +1 more source

Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase Inhibitors

Biochemistry, 2016
The natural product α-hydroxytropolones manicol and β-thujaplicinol inhibit replication of herpes simplex viruses 1 and 2 (HSV-1 and HSV-2, respectively) at nontoxic concentrations.
Marvin J Meyers, Joel D Baines, John A Beutler   +2 more
exaly   +2 more sources

Synthesis of a chemically reactive analog of the initiation codon: its reaction with ribosomes of Escherichia coli.

Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1975
Nitrophenylated 5'-adenylic acid could be employed as primer in a polyribonucleotide nucleotidyltransferase (Micrococcus luteus) reaction to yield 5'-nitrophenylated pA-U-G.
O. Pongs, E. Lanka
semanticscholar   +1 more source

Synthesis of a chemically reactive analog of the nonsense codon U-G-A. Its reaction with ribosomes of Escherichia coli.

Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1975
Nitrophenylated 5'-uridylic acid could be employed as primer in a polyribonucleotide nucleotidyltransferase (Micrococcus luteus) reaction to yield 5'-nitrophenylated Pu-G-A.
O. Pongs, E. Rössner
semanticscholar   +1 more source

Purification and properties of polynucleotide phosphorylase from photosynthetic bacterium Rhodospirillum rubrum.

Journal of Biochemistry (Tokyo), 1980
1. Polynucleotide phosphorylase [polyribonucleotide: orthophosphate nucleotidyltransferase, EC 2.7.7.8] was purified to near homogeneity from the photosynthetic bacterium, Rhodospirillum rubrum. The purified enzyme had a molecular weight of approximately
G. Soe, J. Yamashita
semanticscholar   +1 more source

Effects of polyamines on the degradation of ribonucleic acids by polynucleotide phosphorylase of Micrococcus luteus.

Journal of Biochemistry (Tokyo), 1977
The effects of polyamines on the breakdown of synthetic polynucleotides [poly(A), poly(C), and poly(U)] by polynucleotide phosphorylase [polyribonucleotide: orthophosphate nucleotidyltransferase, EC 2.7.7.8] from Micrococcus luteus have been studied ...
K. Igarashi, H. Kumagai, H. Oguchi, S. Hirose   +3 more
semanticscholar   +1 more source

Modulating populational variance of methyl-guanine methyl transferase expression through miR-181d degradation: a novel mechanism of temozolomide resistance

bioRxiv
Gatikrushna Singh, Shilpi Singh, Iteeshree Mohapatra, Stefan Kim, Mayur Sharma, Johnny Akers, Thien Nguyen, Eric Wong, Margot Martinez Moreno, E. Kokkoli, Shobha Vasudevan, Sean E Lawler, W. El-Deiry, Z. Gokaslan, Clark C. Chen   +14 more
semanticscholar   +1 more source

cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila

Nature, 2021
Amy S-y Lee, Benjamin R Morehouse, Heike Bähre   +2 more
exaly