Results 91 to 100 of about 27,010 (226)

Type 1 Diabetes and Other Autoimmune Diseases—Epidemiology, Pathophysiology and Screening

open access: yesEndocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Individuals with type 1 diabetes exhibit significantly increased prevalence of additional autoimmune diseases. Epidemiological, familial and mechanistic evidence indicates frequent polyautoimmunity and shared genetic and environmental drivers. Coexistence complicates clinical management, and autoantibody‐based detection often identifies preclinical ...
George J. Kahaly   +6 more
wiley   +1 more source

Association of the Endothelial Nitric Oxide Synthase (eNOS) G894T Gene Polymorphism With Type 2 Diabetes Mellitus in a Tunisian Population

open access: yesEndocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
The eNOS G894T polymorphism is a significant genetic risk factor for type 2 diabetes in the studied Tunisian population. The T allele appears to confer susceptibility, likely through mechanisms involving impaired eNOS function, reduced NO production and subsequent endothelial dysfunction.
Afif Ba   +5 more
wiley   +1 more source

Targeting the NEK7/NLRP3 Inflammasome Axis: Synergistic Protection of Intravitreal MCC950 and Systemic Metformin Against Diabetic Retinopathy in Rats

open access: yesEndocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Graphical Abstract ABSTRACT Objective Diabetic retinopathy (DR) is characterised by chronic neuroinflammation where the NLRP3 inflammasome plays a pivotal role. This study investigated the therapeutic potential and underlying mechanism of combining systemic metformin (MET) with intravitreal MCC950, a specific NLRP3 inhibitor, in a rodent model of DR ...
Kexuan Ren, Xiaofeng Li
wiley   +1 more source

A Review of Nanoparticle‐Based Astrocyte Modulation in CNS Disorders: Evaluating the Underexplored Potential of Intranasal Delivery

open access: yesNano Select, Volume 7, Issue 1, January 2026.
Nanoparticle‐driven nose‐to‐brain drug delivery offers a noninvasive approach to bypass the blood–brain barrier (BBB) and directly modulate reactive astrocytes in CNS disorders. This review highlights biodegradable nanoparticles for astrocyte modulation, enhancing drug bioavailability, sustained release, and neuroinflammation control.
Senamile M. Dlamini   +3 more
wiley   +1 more source

Resolution of Noncardiogenic Pulmonary Oedema and Suspected Uraemic Pneumonitis in a Dog With Acute Kidney Injury Treated by Haemodialysis

open access: yesVeterinary Medicine and Science, Volume 12, Issue 1, January 2026.
Noncardiogenic pulmonary oedema (suspected uraemic pneumonitis) secondary to acute kidney injury in a dog. This case suggests that noncardiogenic pulmonary oedema may have been triggered by uraemia and systemic inflammation, and that haemodialysis may have contributed to pulmonary recovery by alleviating the uraemic condition.
Se‐Hoon Kim   +7 more
wiley   +1 more source

Diabetes Induces Accumulation of Carbonylated Proteins in the Rat Retinal Pigment Epithelium Independently of Oxidative Stress

open access: yesFASEB BioAdvances, Volume 8, Issue 1, January 2026.
The retinal pigment epithelium (RPE) plays a crucial role in retinal function, regulating the flow of metabolites and ions between the choroidal blood supply and the outer retina. Early hyperglycemia induced by streptozotocin results in elevated levels of oxidized proteins and lipid peroxidation.
Elena Morales‐Ramírez   +3 more
wiley   +1 more source

Triptorelin therapy for lower urinary tract symptoms (LUTS) in prostate cancer patients: A systematic meta‐analysis

open access: yesBJUI Compass
Objective This systematic meta‐analysis aimed to assess the effectiveness of triptorelin therapy in reducing lower urinary tract symptoms (LUTS) in men with prostate cancer (PCa).
Ravina Barrett, Brian Birch
doaj   +1 more source

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