Results 91 to 100 of about 26,609 (195)

Towards a Safe and Effective Lithium Therapeutic Range for Older Adults With Bipolar Disorder: An ISBD Task Force Systematic Review

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Objectives Lithium is recommended as the first‐line maintenance treatment for older adults with bipolar disorder (OABD). However, age‐related reduction in renal clearance, heightened sensitivity to adverse effects, and drug interactions increase the risk of toxicity and necessitate lower therapeutic serum levels in this population.
Paula V. Nunes, Andrew T. Olagunju, Debbie Zittema, Astha Dhyani, Lei Fu, Peijun Chen, Laura Montejo, Gabriel R. Fries, Lars V. Kessing, Eduard Vieta, Orestes V. Forlenza, Annemieke Dols, Hilary P. Blumberg, Lisa T. Eyler, Kenneth I. Shulman, on behalf of the International Society for Bipolar Disorders (ISBD) Older Adults with Bipolar Disorder (OABD) Lithium Workgroup Task Force   +15 more
wiley   +1 more source

Genetic Insights Into AVP Deficiency: Identification of a Novel AVP Variant and Compilation of a Curated Catalogue of Pathogenic Variants

Clinical Genetics, Volume 110, Issue 2, Page 203-209, August 2026.
We identified a novel pathogenic AVP variant in two Danish families with autosomal dominant inheritance of symptoms of AVP deficiency. In addition, we compiled a catalogue of additionally 109 AVP variants that cause AVP deficiency and demonstrated the advantage of combining expert‐assisted curation, literature search, and online repositories to ensure ...
Jennifa Joseph, Esben Søndergaard, Sine Knorr, Jane Hagelskjær Knudsen, Søren Rittig, Jane Hvarregaard Christensen   +5 more
wiley   +1 more source

Intravesical Botox: An Effective Therapy for Refractory Monosymptomatic Nocturnal Enuresis

Journal of Paediatrics and Child Health, Volume 62, Issue 8, Page 1421-1425, August 2026.
ABSTRACT Aim Monosymptomatic nocturnal enuresis (MNE) significantly impacts many children, with substantial patient groups refractory to conventional first‐line treatments. Intravesical Botox is used for various refractory functional voiding disorders in children, but its efficacy in MNE has not been widely established.
Eliza Szwarcberg, Chris Kimber, Kiarash Taghavi   +2 more
wiley   +1 more source

Validation of an ELISA assay for measurement of the metabolite of serotonin, 5‐hydroxyindole acetic acid (5‐HIAA), in canine urine

Journal of Small Animal Practice, Volume 67, Issue 8, Page 680-685, August 2026.
Objectives Serotonin (5‐hydroxytryptophan), implicated in a number of canine diseases, has a very short half‐life in the serum. Urine concentration of its breakdown product 5‐hydroxyindole acetic acid after an 8 hour fast is a more reliable measure of circulating serotonin in humans.
D. Castillo, A. Swallow, T. Williams, P. Watson   +3 more
wiley   +1 more source

Mitochondrial peptide MOTS‐c suppresses systemic and cardiac inflammasome activation in a diabetic rat model

Experimental Physiology, Volume 111, Issue 8, Page 3742-3752, 1 August 2026.
Abstract Type 2 diabetes mellitus (T2DM) is associated with chronic systemic and cardiac inflammation, contributing to the development of diabetic cardiomyopathy. The mitochondrial‐derived peptide mitochondrial open reading frame of the 12S rRNA type‐C (MOTS‐c) has emerged as a promising regulator of metabolic and inflammatory pathways.
Aimee R. Mills, Antonio de Souza, Toan Pham, Odunayo O. Mugisho   +3 more
wiley   +1 more source

Triptorelin therapy for lower urinary tract symptoms (LUTS) in prostate cancer patients: A systematic meta‐analysis

BJUI Compass
Objective This systematic meta‐analysis aimed to assess the effectiveness of triptorelin therapy in reducing lower urinary tract symptoms (LUTS) in men with prostate cancer (PCa).
Ravina Barrett, Brian Birch
doaj   +1 more source

[Polyuria].

Boletin medico del Hospital Infantil de Mexico, 1981
Polyuria is an important clinical sign that may pass unnoticed to the relatives and to the physician. In this paper, the definition of polyuria and the pathophysiological bases that condition its presence are reviewed. Likewise, the causes of polyuria in pediatric ages are discussed; this allows the clinician to approach the diagnosis in a systematized
openaire   +1 more source

Impact of Hyponatremia and ADH Secretion in MIS-C and COVID-19: An Integrative Approach of Prognostic and Diagnostic Markers

Current Issues in Molecular Biology
The COVID-19 pandemic has introduced challenges in pediatric care, especially due to the emergence of Multisystem Inflammatory Syndrome in Children (MIS-C), a severe condition associated with SARS-CoV-2 infection.
Diana-Andreea Ciortea, Carmen Loredana Petrea (Cliveți), Sorin Ion Berbece, Silvia Fotea, Iolanda Cristina Vivisenco, Gabriela Gurău, Mădălina Nicoleta Matei, Aurel Nechita   +7 more
doaj   +1 more source

Infant Nephrogenic Diabetes Insipidus: Challenges Leading to Delayed Management. [PDF]

Case Rep Med
Stankovic M S, Jankovic Ratkovic M, Mihajlović D, Ignjatović M, Jakovljević M, Cvetković V, Miljković D, Vučić J, Jovančić Petković D, Stanković T, Stanković T.   +10 more
europepmc   +1 more source

Copeptin as a diagnostic tool in a patient with adipsia and hypernatremia. [PDF]

JCEM Case Rep
Elias PCL, de Assunção BR, Dos Santos AC, de Castro M, Elias LLK, Moreira AC.   +5 more
europepmc   +1 more source