Results 31 to 40 of about 29,060 (283)
The inhibition of MDM2 slows cell proliferation and activates apoptosis in ADPKD cell lines
Biology of the Cell, Volume 115, Issue 1, January 2023., 2023 Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a pathology characterised by the formation of kidney cists that impair renal function. The wall of renal cysts is covered with cystic cells that show increased activation of mTOR. Abnormal mTOR activation inhibits autophagy, promotes the degradation of TP53 by the proteasome in a mechanism ...
Simone Patergnani +5 more
wiley +1 more source
Medical Journal of Dr. D.Y. Patil University, 2017 Context: The World Health Organization report suggests that over 19% of the world's diabetic population currently resides in India. Unfortunately, >50% of the diabetics in India are unaware about their diabetic status.
Shivshakti D Pawar +5 more
doaj +1 more source
Frontiers in Endocrinology, 2022 IntroductionWater and electrolyte disturbances are common after pituitary surgery and can generally be classified into transient hypotonic polyuria and transient or permanent diabetes insipidus (DI). The prevalence varies in the literature between 31-51%
Juan Manuel Canelo Moreno +8 more
doaj +1 more source
Clinical Profile of Type 1 Diabetes Mellitus in Children less than 18 years age, in a Tertiary Care Centre, Bhilai, Chhatisgarh, India: A Cross-sectional Study [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: Type 1 Diabetes Mellitus (T1DM) is a very common paediatric endocrine disorder and is increasing each year, particularly in younger children. The T1DM presents as Diabetic Ketoacidosis (DKA) in a significant number of patients.
Shantanu Vijay Gomase, PK Biswal
doaj +1 more source
Transient central diabetes insipidus following ischemic stroke
Indian Journal of Endocrinology and Metabolism, 2013 Central Diabetes Insipidus (CDI) following ischemic infarction of the brain has been described as a rare presentation. Posterior pituitary ischemia has also been postulated as a possible cause of idiopathic CDI. We encountered a young male with bilateral
Muthukrishnan Jayaraman +2 more
doaj +1 more source
Central diabetes insipidus following COVID-19 mRNA vaccination: a case report [PDF]
Kosin Medical Journal, 2023 The coronavirus disease 2019 (COVID-19) has been a major public health emergency worldwide. Vaccines were rapidly developed and approved to prevent the spread of viral infection. However, various side effects of the COVID-19 messenger RNA (mRNA) vaccines
Min-Young Kim +9 more
doaj +1 more source
Clinical Genetics, Volume 103, Issue 2, Page 214-218, February 2023., 2023 Whole exome sequencing of a mother and daughter with isolated Fanconi syndrome revealed a novel variant of GATM, c.965G>C p.(Arg322Pro). Molecular dynamic simulation confirmed that the abnormal protein product would tend to form multimers likely to disrupt mitochondrial function.
Eleanor G. Seaby +6 more
wiley +1 more source
Management of diabetes insipidus in children
Indian Journal of Endocrinology and Metabolism, 2011 Diabetes Insipidus (DI) is a heterogeneous clinical syndrome of disturbance in water balance, characterized by polyuria (urine output > 4 ml/kg/hr), polydypsia (water intake > 2 L/m 2 /d) and failure to thrive.
Garima Mishra, Sudha Rao Chandrashekhar
doaj +1 more source
Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2 [PDF]
, 1999 Deficiency of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) in humans leads to the syndrome of apparent mineralocorticoid excess (SAME), in which cortisol illicitly occupies mineralocorticoid receptors, causing sodium retention, hypokalemia, and ...
Arriza +39 more
core +3 more sources