Results 231 to 240 of about 116,241 (300)

The X‐Ray Crystal Structure of BorF, the Flavin Reductase Subunit of a Two‐Component Flavin‐Dependent Tryptophan Halogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT BorF is a short‐chain flavin reductase from a desert soil bacterium that uses NADH to reduce FAD to FADH2, which is used by the tryptophan‐6‐halogenase BorH to chlorinate tryptophan in the biosynthetic pathway of borregomycin A. The X‐ray crystal structure of BorF bound to FAD was solved to 2.37 Å by molecular replacement.
Zheng Ma, Emily W. Rady, Aravinda J. de Silva, John J. Bellizzi III   +3 more
wiley   +1 more source

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer

Phytotherapy Research, EarlyView.
Schematic illustration of SS‐induced ferroptosis through targeting APT2‐mediated STAT3 palmitoylation in GBC cells. ABSTRACT Gallbladder cancer (GBC), the most prevalent and lethal biliary tract malignancy, lacks effective therapeutic strategies. Solasonine (SS), a bioactive steroidal alkaloid derived from Solanum nigrum L, exhibits antitumor activity ...
Liu‐qing Shi, Jing‐wei Zhao, Jia‐yun Zhu, Cheng Zhao, Zi‐yi Yang, Li‐jia Pan, Ben Ma, Zheng‐yu Chen, Zi‐ying Wang, Chun‐jie Li, Shi‐lei Liu, Jia‐wei Mei, Ping Dong   +12 more
wiley   +1 more source

The characteristics of squall lines in the Southeast Asia region

Quarterly Journal of the Royal Meteorological Society, EarlyView.
Squall lines over the Maritime Continent were analysed using 20 years of IMERG GPM data and classified into four regional clusters. Significant regional differences were found in their size, intensity, lifespan, and propagation. Nighttime squall lines are primarily driven by the convergence of opposing offshore flows and the convergence of monsoonal ...
Jeong‐Yik Diong, Prince Xavier, Muhammad Firdaus Ammar Abdullah, Juliane Schwendike   +3 more
wiley   +1 more source

Security Shaping Sustainability: The Difference Between Securitized and Community‐Based Conservation in Benin

Sustainable Development, EarlyView.
ABSTRACT As global conservation efforts intensify, balancing environmental protection with social sustainability has become increasingly urgent. This study employs a comparative case study approach to examine two natural resource management interventions in northern Benin: one led by African Parks in an insecure zone, and another by TMG Research in a ...
Ramoudane Orou Sannou, Christian P. Schneider   +1 more
wiley   +1 more source

Thermo‐Chemically Modified Silk Scaffolds Reveal Niche‐Driven Regulation of Hematopoiesis and Fibrosis

Small, EarlyView.
We introduce a versatile 3D platform that recreates key physical and biological features of the human bone marrow. By integrating tunable silk biomaterials, stromal cells, and human hematopoietic progenitors, the model captures both healthy and diseased microenvironments, analysis of blood formation, and its disruption in pathological conditions ...
Christian A. Di Buduo, Carolina P. Miguel, Giulia Della Rosa, Vittorio Abbonante, Santo Diprima, Delfina Tosi, Marta Filibian, Daniele Cattaneo, Jugal Kishore Sahoo, Nicola Tirelli, Alessandra Iurlo, Umberto Gianelli, David L. Kaplan, Alessandra Balduini   +13 more
wiley   +1 more source

Macrophage Phenotype–Dependent Protein Corona Formation Governs Ligand Accessibility and Immune Clearance of Biomimetic Nanoparticles

Small, EarlyView.
Macrophage phenotype dictates protein corona composition and immune clearance of biomimetic nanoparticles. M0‐derived membranes minimize opsonin adsorption and complement activation, enabling superior immune evasion and prolonged circulation, thereby providing mechanistic insights for designing long‐circulating nanocarriers.
Tianchang He, Lina Zhu, Jiayi Ding, Xiaoyan Fang, Yu Gao, Volker Mailänder, Daniel Crespy, Katharina Landfester, Shuai Jiang   +8 more
wiley   +1 more source

Comprehensive Evaluation of Bisphenol A Toxicity Reveals Neurobehavioral, Metabolic, and Reproductive Impairments in Girardia tigrina

Environmental Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA), a common industrial chemical used in plastics and consumer products, is increasingly detected in aquatic environments, raising serious concerns about its potential ecological impacts. This study evaluated the sublethal and acute toxic effects of BPA on the freshwater planarian Girardia tigrina, a recognized model for ...
Raquel de Jesus Selestrino, Felipe Schaly, Welligton Luciano Braguini   +2 more
wiley   +1 more source

Variation on Toxic and Inflammatory Potential of Coal Smoke of Different Sources From a Region With High Lung Cancer Risk

Environmental Toxicology, EarlyView.
ABSTRACT Excess lung cancer risk in Xuanwei and Fuyuan, China, has been attributed to household air pollution from use of a locally sourced smoky (bituminous) coal. However, the carcinogenic mechanisms remain unclear. Given the important role of inflammation in lung cancer development, this study compared the proinflammatory potentials of the ...
Yongliang Zhang, Wei Hu, Nathanial Rothman, Dingyu Liu, Jihua Li, Jun Xu, Bofu Ning, Roel Vermeulen, Qing Lan, Flemming R. Cassee, George S. Downward   +10 more
wiley   +1 more source

ChitoSilkBioPatch: A bio‐inspired wound dressing scaffold for antibiotic‐free diabetic wound management

VIEW, EarlyView.
We present ChitoSilkBioPatch, a maleimide‐functionalized chitosan/dACM hydrogel integrated with a stretchable nanopatterned silk mesh to provide intrinsic, antibiotic‐free antibacterial activity and bioactive wound support. The scaffold eliminates S. aureus and P.
Dorsa Dehghan‐Baniani, Babak Mehrjou, Yucong Li, Zhaowei Jiang, Xiaomin Lu, Yin Xiao, Huanxiong Chen, Tsz Lam Yiu, Chi Chiu Wang, Hongkai Wu, Gang Li, Paul K. Chu, Wayne Yuk Wai Lee   +12 more
wiley   +1 more source

Isobaric Molecular Dynamics Study of Liquid Film Boiling. [PDF]

Langmuir
Saha A, Matar OK.
europepmc   +1 more source