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A cell line development vector strategy for improved expression of a trispecific T-cell engager in CHO. [PDF]

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Mistry RK, Nui C, Lambiase G, Ray D, Kearsey L, Hitchcock N, Grassi L, Elgendy R, Fleming J, Broughton AC, Zhao P, Chiang CI, Shah P, Cyr M, Walseng E, Mazor Y, Hatton D, Dunn S.   +17 more
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Preferential precipitation of acidic variants from monoclonal antibody pools

Biotechnology and Bioengineering, 2022
AbstractMicroheterogeneity of monoclonal antibodies (mAbs) can impact their activity and stability. Formation of charge variants is considered as the most important source of the microheterogeneity. In particular, controlling the content of the acidic species is often of major importance for the production process and regulatory approval of therapeutic
Tomasz Rumanek, Michał Kołodziej, Wojciech Piątkowski, Dorota Antos   +3 more
openaire   +2 more sources

New reservoirs of HLA alleles: pools of rare variants enhance immune defense

Trends in Genetics, 2012
Highly polymorphic exons of the major histocompatibility complex (MHC, or HLA in humans) encode critical amino acids that bind foreign peptides. Recognition of the peptide-MHC complexes by T cells initiates the adaptive immune response. The particular structure of these exons facilitates gene conversion(GC) events, leading to the generation of new ...
William, Klitz, Philip, Hedrick, Edward J, Louis   +2 more
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Coupling of chromatography and precipitation for adjusting acidic variant content in a monoclonal antibody pool

Journal of Chromatography A, 2023
The acidic charge variants (av) of monoclonal antibodies (mAb) are often reported to have reduced therapeutic potency compared with the main (mv) and basic variants (bv), therefore reduction in the av content in mAb pools is often prioritized over reduction in the bv content.
Patrycja Zimoch, Tomasz Rumanek, Michał Kołodziej, Wojciech Piątkowski, Dorota Antos   +4 more
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Variant design of the sports center pool cover

Agro-industrial complex: problems and prospects of development
The article describes three variants of the load-bearing structures of the pool cover. The calculation of the strength and deformability of the studied structures made of glued wood and plywood is presented. The results of the comparison on the consumption of materials, as well as labor costs of products are presented.
Andrey O. Glomozda, Alexander I. Turov
openaire   +1 more source