Results 231 to 240 of about 127,668 (260)

Spatial mapping of barcoded, brain-tropic AAVs using multiplexed RNA <i>in situ</i> hybridization. [PDF]

Mol Ther Adv
Fouani Y, Oti M, Jarosch S, Blazevic D, Duechs MJ, Ketterer S, Becker R, Abele S, Strobel B, Schoenberger T, Alanis-Lobato G, Rust W, Schoen C, Klugmann M, Maier U, Doerr J, Michelfelder S.   +16 more
europepmc   +1 more source

T cell-mediated protection against lethal SARS-CoV-2 challenge by a synthetic long peptide vaccine targeting conserved CD4+ and CD8+ T cell epitopes

Gracht ETvd, Pardieck IN, Duikeren Sv, Rijn Pv, Veerkamp DM, de Graaf JF, Kwappenberg K, Kamerling IM, Kruithof AC, Plas JLvd, Linger ME, Horst JRB, Myeni SK, Krebber W, Hooftman L, Beenakker TJ, Arens R, Melief CJ, Wiekmeijer A.   +18 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

DDPCR SARSCOV2 VARIANT DETECTION IN POOLED SAMPLES

2023
Datasets for publishing in INTERNATIONAL JOURNAL OF INFECTIOUS ...
Franco Paredes, Juliana I. Sesma, Antonella Pacini, Yanina Agnella, Sofía Heckel, Guadalupe Ibarra, Maria Victoria Petrelli, Marilina Perez, Maria Laura Piskulic, María Belén Allasia, Alejandro Colaneri   +10 more
openaire   +1 more source

Preferential precipitation of acidic variants from monoclonal antibody pools

Biotechnology and Bioengineering, 2022
AbstractMicroheterogeneity of monoclonal antibodies (mAbs) can impact their activity and stability. Formation of charge variants is considered as the most important source of the microheterogeneity. In particular, controlling the content of the acidic species is often of major importance for the production process and regulatory approval of therapeutic
Tomasz Rumanek, Michał Kołodziej, Wojciech Piątkowski, Dorota Antos   +3 more
openaire   +2 more sources

The Quest for Rare Variants: Pooled Multiplexed Next Generation Sequencing in Plants [PDF]

Frontiers in Plant Science, 2012
Next generation sequencing (NGS) instruments produce an unprecedented amount of sequence data at contained costs. This gives researchers the possibility of designing studies with adequate power to identify rare variants at a fraction of the economic and labor resources required by individual Sanger sequencing.
Fabio Marroni, Sara Pinosio, Michele Morgante   +2 more
exaly   +6 more sources

Preferential precipitation for reducing acidic variant content in monoclonal antibody pools

SSRN Electronic Journal, 2022
Microheterogeneity of mAbs can impact their activity and stability. Formation of charge variants is considered as the most important source the microheterogeneity. In particular, controlling the content of the acidic species is often a major importance for the production process and the regulatory approval of therapeutic proteins.
Dorota Antos, Tomasz Rumanek, Michal Kolodziej, Wojciech Piatkowski   +3 more
openaire   +1 more source

Deep sequencing to reveal new variants in pooled DNA samples

Human Mutation, 2009
We evaluated massive parallel sequencing and long-range PCR (LRP) for rare variant detection and allele frequency estimation in pooled DNA samples. Exons 2 to 16 of the MUTYH gene were analyzed in breast cancer patients with Illumina's (Solexa) technology.
Out, Astrid A, van Minderhout, Ivonne J H M, Goeman, Jelle J, Ariyurek, Yavuz, Ossowski, Stephan, Schneeberger, Korbinian, Weigel, Detlef, van Galen, Michiel, Taschner, Peter E M, Tops, Carli M J, Breuning, Martijn H, van Ommen, Gert-Jan B, den Dunnen, Johan T, Devilee, Peter, Hes, Frederik J   +14 more
openaire   +4 more sources

Coupling of chromatography and precipitation for adjusting acidic variant content in a monoclonal antibody pool

Journal of Chromatography A, 2023
The acidic charge variants (av) of monoclonal antibodies (mAb) are often reported to have reduced therapeutic potency compared with the main (mv) and basic variants (bv), therefore reduction in the av content in mAb pools is often prioritized over reduction in the bv content.
Patrycja Zimoch, Tomasz Rumanek, Michał Kołodziej, Wojciech Piątkowski, Dorota Antos   +4 more
openaire   +2 more sources

Variant design of the sports center pool cover

Agro-industrial complex: problems and prospects of development
The article describes three variants of the load-bearing structures of the pool cover. The calculation of the strength and deformability of the studied structures made of glued wood and plywood is presented. The results of the comparison on the consumption of materials, as well as labor costs of products are presented.
Andrey O. Glomozda, Alexander I. Turov
openaire   +1 more source