Results 51 to 60 of about 122,799 (164)

Pool-seq of diverse apple germplasm reveals candidate loci underlying ripening time, phenolic content, and softening

Fruit Research, 2023
Ripening time, softening, and phenolic content are phenotypes of considerable commercial importance in apples. Identifying causal genetic variants controlling these traits not only advances marker-assisted breeding, but it is also an essential step for ...
Thomas Davies, Sean Myles
doaj   +1 more source

Differential Control of the Releasable Vesicle Pools by SNAP-25 Splice Variants and SNAP-23 [PDF]

Cell, 2003
The SNARE complex, consisting of synaptobrevin, syntaxin, and SNAP-25, is essential for calcium-triggered exocytosis in neurosecretory cells. Little is known, however, about how developmentally regulated isoforms and other cognate SNARE components regulate vesicular fusion.
Sørensen, J., Nagy, G., Varoqueaux, F., Nehring, R., Brose, N., Wilson, M., Neher, E.   +6 more
openaire   +5 more sources

CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology

Heliyon, 2018
We have previously shown that immunological processes in the brain during α-synuclein-induced neurodegeneration vary depending on the presence or absence of cell death.
Mads N. Olesen, Josefine R. Christiansen, Steen Vang Petersen, Poul Henning Jensen, Wojciech Paslawski, Marina Romero-Ramos, Vanesa Sanchez-Guajardo   +6 more
doaj   +1 more source

Design of DNA Pooling to Allow Incorporation of Covariates in Rare Variants Analysis

PLoS ONE, 2014
Rapid advances in next-generation sequencing technologies facilitate genetic association studies of an increasingly wide array of rare variants. To capture the rare or less common variants, a large number of individuals will be needed. However, the cost of a large scale study using whole genome or exome sequencing is still high.
Weihua Guan, Chun Li
openaire   +4 more sources

Towards prediction of microstructure during laser based additive manufacturing process of Co-Cr-Mo powder beds

Materials & Design, 2020
Processing parameters during laser based additive manufacturing affect the fluid flow, heat transfer and solidification characteristics in the melt pool, leading to microstructural variants of texture, grain size, and morphology.
Pikee Priya, Brian Mercer, Shenyan Huang, Mohamed Aboukhatwa, Lang Yuan, Santanu Chaudhuri   +5 more
doaj   +1 more source

fshr: a fish sex-determining locus shows variable incomplete penetrance across flathead grey mullet populations

iScience, 2021
Summary: Whole-genome sequencing data were produced from a single flathead grey mullet female and assembled into a draft genome sequence, whereas publicly available sequence data were used to obtain a male draft sequence. Two pools, each consisting of 60
Serena Ferraresso, Luca Bargelloni, Massimiliano Babbucci, Rita Cannas, Maria Cristina Follesa, Laura Carugati, Riccardo Melis, Angelo Cau, Manos Koutrakis, Argyrios Sapounidis, Donatella Crosetti, Tomaso Patarnello   +11 more
doaj   +1 more source

International Lung Cancer Consortium: Pooled Analysis of Sequence Variants in DNA Repair and Cell Cycle Pathways [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2008
Abstract Background: The International Lung Cancer Consortium was established in 2004. To clarify the role of DNA repair genes in lung cancer susceptibility, we conducted a pooled analysis of genetic variants in DNA repair pathways, whose associations have been investigated by at least 3 individual studies.
Hung RJ, Christiani DC, Risch A, Popanda O, Haugen A, Zienolddiny S, Benhamou S, Bouchardy C, Lan Q, Spitz MR, Wichmann HE, LeMarchand L, VINEIS, Paolo, MATULLO, Giuseppe, Kiyohara C, Zhang ZF, Pezeshki B, Harris C, Mechanic L, Seow A, Ng DP, Szeszenia Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Caporaso N, Chen C, Duell EJ, Goodman G, Field JK, Houlston RS, Hong YC, Landi MT, Lazarus P, Muscat J, McLaughlin J, Schwartz AG, Shen H, Stucker I, Tajima K, Matsuo K, Thun M, Yang P, Wiencke J, Andrew AS, Monnier S, Boffetta P, Brennan P.   +52 more
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Protocol to perform multiplexed assays of variant effect using curated loci prime editing

STAR Protocols
Summary: Multiplexed assays of variant effect (MAVEs) perform simultaneous characterization of many variants. Here, we present a protocol to perform MAVEs using curated loci prime editing (cliPE), an accessible experimental pipeline that enables prime ...
Carina G. Biar, Nicholas Bodkin, Gemma L. Carvill, Jeffrey D. Calhoun   +3 more
doaj   +1 more source

Genomic surveillance of SARS-CoV-2 variants using pooled WGS

Scientific Reports
This study presents the development and validation of a genomic surveillance strategy using Whole Genome Sequencing (WGS) on normalized pooled samples to detect and monitor SARS-CoV-2 variants. A bioinformatics pipeline was designed specifically for analyzing pooled WGS data and was validated using simulated datasets, pooled samples of reference ...
Inho Park, Yoonjung Kim, Min Hyuk Choi, Kyung-A Lee   +3 more
openaire   +3 more sources

MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort [PDF]

The Lancet Child & Adolescent Health, 2019
Germline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in
Pellegrini C, Botta F, Massi D, Martorelli C, Facchetti F, Gandini S, Maisonneuve P, Avril MF, Demenais F, Bressac-de Paillerets B, Hoiom V, Cust AE, Anton-Culver H, Gruber SB, Gallagher RP, Marrett L, Zanetti R, Dwyer T, Thomas NE, Begg CB, Berwick M, Puig S, Potrony M, Nagore E, Ghiorzo P, Menin C, Manganoni AM, Rodolfo M, Brugnara S, Passoni E, Sekulovic LK, Baldini F, Guida G, Stratigos A, Ozdemir F, Ayala F, Fernandez-de-Misa R, Quaglino P, Ribas G, Romanini A, Migliano E, Stanganelli I, Kanetsky PA, Pizzichetta MA, Garcia-Borron JC, Nan H, Landi MT, Little J, Newton-Bishop J, Sera F, Fargnoli MC, Raimondi S, Massi D, Pastorino L, Menin C, Alaibac M, Manganoni AM, Facchetti F, Rodolfo M, Ferrari A, Valeri B, Fargnoli MC, Pellegrini C, Brugnara S, Sicher M, Mangiola D, Passoni E, Nazzaro G, Baldini F, Tosti G, Gandini S, Mazzarol G, Guida G, Guida S, Giudice G, Ayala F, Quaglino P, Ribero S, Astrua C, Romanini A, Migliano E, Stanganelli I, Mazzoni L, Pizzichetta MA, Berwick M, Begg C, Orlow I, Mujumdar U, Hummer A, Busam K, Roy P, Cotignola J, Monroe Y, Armstrong B, Kricker A, Litchfield M, Tucker P, Stephens N, Gallagher R, Switzer T, Marrett L, Theis B, From L, Chowdhury N, Vanasse L, Purdue M, Northrup D, Zanetti R, Rosso S, Sacerdote C, Anton-Culver H, Leighton N, Gildea M, Gruber S, Bonner J, Jeter J, Klotz J, Wilcox H, Weiss H, Millikan R, Thomas N, Mattingly D, Player J, Tse CK, Rebbeck T, Kanetsky P, Walker A, Panossian S, Mohrenweiser H, Setlow R, Raimondi S, Autier P, Fargnoli MC, Kanetsky PA, Landi MT, Little J, Newton-Bishop J, Sera F, Caini S, Gandini S, Maisonneuve P, Hofman A, Kayser M, Liu F, Nijsten T, Uitterlinden AG, Kumar R, Bishop T, Elliott F, Nagore E, Lazovich D, Polsky D, Hansson J, Hoiom V, Ghiorzo P, Pastorino L, Gruis NA, Bavinck JNB, Aguilera P, Badenas C, Carrera C, Gimenez-Xavier P, Tell-Marti G, Dwyer T, Blizzard L, Cochrane J, Branicki W, Debniak T, Morling N, Johansen P, Mayne S, Bale A, Cartmel B, Ferrucci L, Pfeiffer R, Palmieri G, Ribas G, Menin C, Stratigos A, Kypreou K, Bowcock A, Cornelius L, Council ML, Motokawa T, Anno S, Helsing P, Andresen PA, Guida G, Guida S, Wong TH   +189 more
openaire   +18 more sources