Results 81 to 90 of about 122,799 (164)

Investigation of rare and low-frequency variants using high-throughput sequencing with pooled DNA samples

Scientific Reports, 2016
AbstractHigh-throughput sequencing using pooled DNA samples can facilitate genome-wide studies on rare and low-frequency variants in a large population. Some major questions concerning the pooling sequencing strategy are whether rare and low-frequency variants can be detected reliably, and whether estimated minor allele frequencies (MAFs) can represent
Wang J, Skoog T, Einarsdottir E, Kaartokallio T, Laivuori H, Grauers A, Gerdhem P, Hytönen M, Lohi H, Kere J, Jiao H   +10 more
openaire   +5 more sources

Differential Evolution Algorithm with Three Mutation Operators for Global Optimization

Mathematics
Differential evolution algorithm is a very powerful and recently proposed evolutionary algorithm. Generally, only a mutation operator and predefined parameter values of differential evolution algorithm are utilized to solve various optimization problems,
Xuming Wang, Xiaobing Yu
doaj   +1 more source

Joint rare variant association test of the average and individual effects for sequencing studies.

PLoS ONE, 2012
For many complex traits, single nucleotide polymorphisms (SNPs) identified from genome-wide association studies (GWAS) only explain a small percentage of heritability.
Yuanjia Wang, Yin-Hsiu Chen, Qiong Yang
doaj   +1 more source

Eco-evolutionary dynamics of adapting pathogens and host immunity

eLife
As pathogens spread in a population of hosts, immunity is built up, and the pool of susceptible individuals are depleted. This generates selective pressure, to which many human RNA viruses, such as influenza virus or SARS-CoV-2, respond with rapid ...
Pierre Barrat-Charlaix, Richard A Neher
doaj   +1 more source

Long-term analysis of humoral responses and spike-specific T cell memory to Omicron variants after different COVID-19 vaccine regimens

Frontiers in Immunology
BackgroundThe emergence of SARS-CoV-2 variants has raised concerns about the sustainability of vaccine-induced immunity. Little is known about the long-term humoral responses and spike-specific T cell memory to Omicron variants, with specific attention ...
Chia-Lo Ho, Li-Chen Yen, Hong-Wei Huang, Chun-Chi Lu, Yi-Jen Hung, Ching-Len Liao, Ching-Len Liao, Chin-Mao Hung, Kuo-Chou Chiu, Kuo-Chou Chiu, Kuo-Chou Chiu   +10 more
doaj   +1 more source

Biallelic BRCA2 variants induce premature ovarian insufficiency by impaired meiotic homologous recombination

Communications Biology
The DNA damage response plays a pivotal role in ovarian aging. Breast cancer susceptibility gene 2 (BRCA2), which participates in homologous recombination (HR), is a key regulator of natural menopause. Rare BRCA2 variants have been identified in patients
Xinyi Wu, Qian Zhang, Chang Li, Shuning Zhuang, Hongyuan Liu, Xue Jiao, Shidou Zhao, Yingying Qin, Ting Guo   +8 more
doaj   +1 more source

DoBSeqWF: a framework for sensitive detection of individual genetic variation in pooled sequencing data. [PDF]

NAR Genom Bioinform
Cort Nielsen M, Hagen CM, Stoltze UK, Hansen TVO, Nyegaard M, Hjalgrim H, Bækvad-Hansen M, Byrjalsen A, Schmiegelow K, Wadt K, Bybjerg-Grauholm J, Rasmussen S.   +11 more
europepmc   +1 more source

Methods for safely sharing dual-use genetic data. [PDF]

Front Microbiol
Sawaya S, Lo CC, Li PE, Hovde B, Chain P.   +4 more
europepmc   +1 more source

Evaluation of optimal pooling strategies for Mpox virus genomic surveillance using the Illumina Viral Surveillance Panel on the iSeq100 platform in outbreak settings. [PDF]

BMJ Public Health
Nguinkal JA, Melo AM, Nzoyikorera N, Jurgen M, Affara M, Gehre F.   +5 more
europepmc   +1 more source

Decoding RNA-protein interactions using high-throughput methods. [PDF]

RNA Biol
Régis M, Pulcina P, Kretov DA.
europepmc   +1 more source