Results 121 to 130 of about 1,071,464 (297)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Does High Tech Exports Really Matter for Economic Growth a Panel Approach for Upper Middle-Income Economies

open access: yesOnline Academic Journal of Information Technology, 2018
In this study, we analyzed the data about the technological diversification of export composition of upper middle-income countries and the impact of the technological composition of exported goods on GDP growth.
Oğuz Demir
doaj   +1 more source

Money Demand in Mongolia: A Panel Data Analysis [PDF]

open access: yes
This paper investigates if there is a significant money demand relationship in Mongolia. The data used is a panel data set covering 22 Mongolian regions over the period 1993-99.
Torsten Sl¯k
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Panel Estimation of the Impact of Uncertainty on Investment in the Industrial Countries [PDF]

open access: yes
There is growing interest in economic uncertainty and its long run impact on investment. In previous work the authors established clear evidence of the negative impact of exchange rate uncertainty on investment in the G7, measured using a GARCH approach,
Byrne, Joseph B, E. Philip Davis
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Long-run relationship between crop-biodiversity and cereal production under the CAP reform: evidence from Italian regions [PDF]

open access: yes
Biodiversity has a prominent role in defining and preserving ecosystem well-being; the analysis of biodiversity effects on agricultural production is well documented.
Elisa Gatto, Guido Signorino
core  

Prevalence of Dyskinesia and OFF by 30-Minute Intervals Through the Day and Assessment of Daily Episodes of Dyskinesia and OFF: Novel Analyses of Diary Data from Gocovri Pivotal Trials. [PDF]

open access: yes, 2019
BACKGROUND: Parkinson\u27s disease (PD) patients using levodopa commonly develop dyskinesia and OFF episodes that reduce quality of life. OBJECTIVE: Evaluate prevalence of troublesome dyskinesia and OFF through the day, assessed by 30-minute intervals ...
Elmer, Lawrence W.   +8 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Productivity Growth and Convergence in U.S. Agriculture: New Cointegration Panel Data Results [PDF]

open access: yes
Dynamic effects of health and inter-state and inter-industry knowledge spillovers, total factor productivity (TFP) growth and convergence in U.S. agriculture are examined using recently developed procedures for panel data and a growth accounting model ...
C. Richard Shumway   +3 more
core  

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