Results 61 to 70 of about 701,410 (306)

Methodological Insight Into Mosquito Microbiome Studies

Frontiers in Cellular and Infection Microbiology, 2020
Symbiotic bacteria affect competence for pathogen transmission in insect vectors, including mosquitoes. However, knowledge on mosquito-microbiome-pathogen interactions remains limited, largely due to methodological reasons.
Sonia M. Rodríguez-Ruano, Eliška Juhaňáková, Jakub Vávra, Eva Nováková, Eva Nováková   +4 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The Potential of Servicizing as a Green Business Model [PDF]

, 2015
It has been argued that servicizing business models, under which a firm sells the use of a product rather than the product itself, are environmentally beneficial.
Ioannis Bellos, Vishal V. Agrawal
core  

Socially Optimal Mining Pools

, 2017
Mining for Bitcoins is a high-risk high-reward activity. Miners, seeking to reduce their variance and earn steadier rewards, collaborate in pooling strategies where they jointly mine for Bitcoins.
A Laszka, B Johnson, DM Kreps, LG Epstein, O Schrijvers, P Samuelson, R Pass, S Frederick, S Nakamoto   +8 more
core   +1 more source

Improving the accuracy of the information retrieval evaluation process by considering unjudged document lists from the relevant judgment sets

Information Research: An International Electronic Journal
Introduction. To improve user satisfaction and loyalty to the search engines, the performance of the retrieval systems has to be better in terms of the number of relevant documents retrieved.
Minnu Helen Joseph, SriDevi Ravana
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Reliable Information Retrieval Systems Performance Evaluation: A Review

IEEE Access
With the progressive and availability of various search tools, interest in the evaluation of information retrieval based on user perspective has grown tremendously among researchers.
Minnu Helen Joseph, Sri Devi Ravana
doaj   +1 more source

Pooled testing: A tool to increase efficiency of infant HIV diagnosis and virological monitoring

African Journal of Laboratory Medicine, 2020
Background: Pooled testing, or pooling, has been used for decades to efficiently diagnose relatively rare conditions, such as infection in blood donors.
Wolfgang Preiser, Gert U. van Zyl
doaj   +1 more source