Results 101 to 110 of about 368,691 (302)

Feasibility Study to Evaluate the Proportion of Cancer Attributable to Modifiable Factors of Risk in Peru and Latin America

Revista de la Facultad de Medicina Humana, 2020
Objective: To evaluate the feasibility of the methodological proposal to estimate the incidence and mortality due to cancer attributable to modifiable risk factors for Peru and Latin America.
Jhony A. De La Cruz Vargas, Willy Cesar Ramos, Willer Chanduví, Ruben Espinoza, Nadia Guerrero, Joan Loayza-Castro, Alfonso Gutiérrez Aguado, Ronald Carpio, Manuel Loayza Alarico   +8 more
doaj   +1 more source

Population fraction of Parkinson’s disease attributable to preventable risk factors

npj Parkinson's Disease, 2023
Parkinson’s disease is the fastest-growing neurologic disease with seemingly no means of prevention. Intrinsic risk factors (age, sex, and genetics) are inescapable, but environmental factors are not.
Haydeh Payami, Gwendolyn Cohen, Charles F. Murchison, Timothy R. Sampson, David G. Standaert, Zachary D. Wallen   +5 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Potential impact of controlling opium use prevalence on future cancer incidence in IranResearch in context

EClinicalMedicine
Summary: Background: The International Agency for Research on Cancer (IARC) recently classified opium consumption as carcinogenic to humans. This study aimed to estimate the potential reduction in incident cancers by 2035 in Iran, which accounts for 42%
Saeed Nemati, Amir Reza Dardashti, Elham Mohebbi, Farin Kamangar, Reza Malekzadeh, Kazem Zendehdel, Mahdi Sheikh   +6 more
doaj   +1 more source

Cancers in Australia in 2010 attributable to the consumption of alcohol

Australian and New Zealand Journal of Public Health, 2015
Objective: To estimate the proportion and numbers of cancers occurring in Australia in 2010 that are attributable to alcohol consumption. Methods: We estimated the population attributable fraction (PAF) of cancers causally associated with alcohol ...
Nirmala Pandeya, Louise F. Wilson, Penelope M. Webb, Rachel E. Neale, Christopher J. Bain, David C. Whiteman   +5 more
doaj   +1 more source

Monitoring response to hepatitis B and C in EU/EEA: testing policies, availability of data on care cascade and chronic viral hepatitis-related mortality – results from two surveys (2016) [PDF]

, 2018
Objectives: The World Health Organization (WHO) developed a European Regional Action Plan (EAP) to fast-track action towards the goal of eliminating viral hepatitis. Robust monitoring is essential to assess national programme performance.
De Brujin, European Centre for Disease Prevention and Control, European Centre for Disease Prevention and Control, European Centre for Disease Prevention and Control, European Centre for Disease Prevention and Control, European Centre for Disease Prevention and Control, European Centre for Disease Prevention and Control, European Centre for Disease Prevention and Control, Iyengar, World Health Organisation, World Health Organisation, World Health Organisation   +11 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

[Population attributable fraction: estimation and interpretation].

Gaceta sanitaria, 2015
The goal of this paper is to revise the concept, estimation methods, and interpretations of the population attributable fraction. From the usual formula of the population attributable fraction: (Ip ­ I₀) / Ip, where Ip is the cumulative incidence in the overall population, and I₀ is the cumulative incidence in the non-exposed group, other formulae are ...
J, Llorca, C, Fariñas-Álvareza, M, Delgado-Rodrígueza   +2 more
openaire   +1 more source