Results 111 to 120 of about 368,691 (302)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Risk of non-cancer respiratory diseases attributed to humidifier disinfectant exposure in Koreans: age-period-cohort and differences-in-difference analyses [PDF]

Epidemiology and Health
OBJECTIVES Humidifier disinfectants (HDs) were sold in Korea from 1994 until their recall in 2011. We examined the incidence patterns of 8 respiratory diseases before and after the HD recall and estimated the attributable risk in the Korean population ...
Jaiyong Kim, Kyoung Sook Jeong, Seungyeon Heo, Younghee Kim, Jungyun Lim, Sol Yu, Suejin Kim, Sun-Kyoung Shin, Hae-Kwan Cheong, Mina Ha, Epidemiology Expert Committee for Reviewing the Epidemiological Correlations between Humidifier Disinfectant Exposure and Health Effects   +10 more
doaj   +1 more source

Estimating the burden of disease attributable to smoking in South Africa in 2000 [PDF]

, 2007
Objectives. To quantify the burden of disease attributable to smoking in South Africa for 2000. Design. The absolute difference between observed lung cancer death rate and the level in non-smokers, adjusted for occupational and indoor exposure to lung ...
Groenewald, Pam, Vos, Theo, Norman, Rosana, Laubscher, Ria, Van Walbeek, Corne, Saloojee, Yussuf, Sitas, Freddy, Bradshaw, Debbie, The South African Comparative Risk Assessment Collaborating Group   +8 more
core   +1 more source

Gestational age at delivery and special educational need: retrospective cohort study of 407,503 schoolchildren [PDF]

, 2010
<STRONG>Background</STRONG> Previous studies have demonstrated an association between preterm delivery and increased risk of special educational need (SEN).
A Brady, AL Rickards, AT Bhutta, BE Stephens, CM McCarton, D Wolke, Daniel F. MacKay, G Wiener, Gordon C. S. Smith, I Kirkegaard, J Briscoe, J Cuzick, Jill P. Pell, LA Foulder-Hughes, M Lagerstrom, M Ornstein, MG Eide, MJ Davidoff, P Royston, PJ Anderson, RG Record, Richard Dobbie, S Campbell, S Yang, SK Cole, Tze Kin Lau   +25 more
core   +4 more sources

Accounting for biases in survey-based estimates of population attributable fractions [PDF]

Population Health Metrics, 2019
Abstract Background This paper discusses best practices for estimating fractions of mortality attributable to health exposures in survey data that are biased by observed confounders and unobserved endogenous selection. Extant research has shown that estimates of population attributable fractions (PAF) from the formula using the proportion of deceased ...
Ryan Masters, Eric Reither
openaire   +5 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Orbit determination of space objects based on sparse optical data [PDF]

, 2010
While building up a catalog of Earth orbiting objects, if the available optical observations are sparse, not deliberate follow ups of specific objects, no orbit determination is possible without previous correlation of observations obtained at different ...
A. Milani, A. Rossi, Choc, D. Farnocchia, Farnocchia, G. Tommei, Gronchi, Jehn, Maruskin, Milani, Milani, Milani, Milani, Milani, Milani, Musci, R. Jehn, Rossi, Schildknecht, Schildknecht, Schildknecht, T. Schildknecht, Tommei, Valk, Vokrouhlický   +24 more
core   +2 more sources

Recommendation on unbiased estimation of population attributable fraction calculated in “prevalence and risk factors of active pulmonary tuberculosis among elderly people in China: a population based cross-sectional study”

Infectious Diseases of Poverty, 2019
Population attributable fraction (PAF) refers to the proportion of all cases with a particular outcome in a population that could be prevented by eliminating a specific exposure.
A. Khosravi, M. Mansournia
semanticscholar   +1 more source