Results 41 to 50 of about 6,246,292 (318)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

POPULATION GENETICS

open access: yesAnnual Review of Genetics, 1967
Uploaded by Plazi for TaxoDros. We do not have abstracts.
openaire   +4 more sources

On Gossip and Populations

open access: yes, 2010
Gossip protocols are simple, robust and scalable and have been consistently applied to many (mostly wired) distributed systems. Nevertheless, most validation in this area has been so far empirical and there is a clear lack of a theoretical counterpart to characterize what can and cannot be computed with gossip protocols.
Bertier, Marin   +2 more
openaire   +3 more sources

Practice Patterns for Acute Ischemic Stroke Workup: A Longitudinal Population‐Based Study

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundWe examined practice patterns of inpatient testing to identify stroke etiologies and treatable risk factors for acute ischemic stroke recurrence.
Matthew C. Loftspring   +11 more
doaj   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

Contemporary Demographic Characteristics of Municipality of Bela Palanka [PDF]

open access: yesДемографија, 2014
Favourable geo-traffic position of Bela Palanka and its surroundings has always been attractive for settlement of population. This is witnessed by numerous archaeological sites from prehistoric, Roman and Byzantine periods.
Dušan Živković
doaj  

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

Imaginary populations [PDF]

open access: yesAnimal Biodiversity and Conservationa, 2010
A few years ago, Camus & Lima (2002) wrote an essay to stimulate ecologists to think about how we define and use a fundamental concept in ecology: the population. They concluded, concurring with Berryman (2002), that a population is ‘a group of individuals of the same species that live together in an area of sufficient size to permit normal ...
openaire   +6 more sources

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