Results 51 to 60 of about 6,246,292 (318)
Pandemics and populations [PDF]
The European Journal of Contraception & Reproductive Health Care, 2020 2020 was the year of the COVID-19 pandemic, which overshadowed all other global challenges we face.
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundClinical guidelines recommend using predicted atherosclerotic cardiovascular disease (ASCVD) risk to inform treatment decisions. The objective was to compare the contribution of changes in modifiable risk factors versus aging to the development
Adam P. Bress +11 more
doaj +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
, 2005 This timely and important Handbook takes stock of progress made in our understanding of what sustainable development actually is and how it can be measured and achieved.
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FEBS Letters, EarlyView.This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter +8 more
wiley +1 more source
Effective Population Size of Korean Populations [PDF]
Genomics & Informatics, 2014 Recently, new methods have been developed for estimating the current and recent changes in effective population sizes. Based on the methods, the effective population sizes of Korean populations were estimated using data from the Korean Association Resource (KARE) project. The overall changes in the population sizes of the total populations were similar
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International Indigenous Policy Journal, 2014 This article primarily aims to demonstrate how diversity is reflected among urban Aboriginal peoples in Canada. Secondly, it uncovers if and how preventive health services in the province of Ontario, Canada are responsive to this diversity. Data for this
Hasu Ghosh, Institute of Population Health +1 more
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Revista Brasileira de Fruticultura, 2007 O bacurizeiro é espécie frutífera promissora, devido as amplas possibilidades que apresenta como planta de uso múltiplo (madeira e fruto), podendo vir a se constituir, em breve, em nova alternativa de cultura perene para a Amazônia.
Walnice Maria Oliveira do Nascimento +2 more
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FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source