Results 81 to 90 of about 5,795,689 (249)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Midwives\' Experiences of Implementing Iran\'s Pronatalist Population Policy: A Qualitative Study [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: In response to declining total fertility rates, concerns about population replacement, and the spread of low-fertility patterns, a pronatalist population policy was approved in Iran under the “Youthful Population and Protection of
Shahnaz Kohan, Fatemeh Mokhtari, Marzieh Ghasemi Goujani, Kiana Saberi, Zahra Izadi Pour   +4 more
doaj  

ІСТОРИЧНИЙ РОЗВИТОК ПЕРЕЯСЛАВЩИНИ: СОЦІАЛЬНО-ГЕОГРАФІЧНИЙ АСПЕКТ

Простір в історичних дослідженнях, 2020
У статті розглянуто аспекти історичного розвитку Переяславщини в умовах адміністративно-територіальних змін упродовж періоду її писемної історії, наведено демографічно-статистичні та інші відомості, щодо населення краю, місць його компактного проживання.
Тарас Нагайко
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Human-geographical concept of the regional geodemographic system

Časopis Socìalʹno-Ekonomìčnoï Geografìï. Часопис соціально-економічної географії, 2017
The synergetic analysis of geodemographic researches indicates that they can be solved with use of modern technologies of management. according to the theory of a sotsioaktogenez, for this purpose it is necessary to define and formulate accurately the ...
Kateryna Sehida
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Population and conservation threats to the vulnerable Sarus crane Grus antigone in Nepal

Ecology and Evolution
Globally, biodiversity is declining due to habitat loss and degradation, over‐exploitation, climate change, invasive species, pollution, and infrastructure development. These threats affect the populations of large waterbird species, such as Sarus crane (
Hari Prasad Sharma, Hem Bahadur Katuwal, Sandeep Regmi, Rajendra Narsingh Suwal, Rashmi Acharya, Amrit Nepali, Sabin KC, Bishnu Aryal, Krishna Tamang, Basudha Rawal, Amir Basnet, Bashu Dev Baral, Surya Devkota, Sagar Parajuli, Niraj Regmi, Pradip Kandel, Bishal Subedi, Hari Sharan Giri, Samjhana Kawan, Gokarna Jung Thapa, Bishnu Prasad Bhattarai   +20 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source