Results 61 to 70 of about 236,721 (282)

Attributable Risk Function in the Proportional Hazards Model [PDF]

, 2005
As an epidemiological parameter, the population attributable fraction is an important measure to quantify the public health attributable risk of an exposure to morbidity and mortality.
Chen, Ying Qing, Hu, Chengcheng, Wang, Yan   +2 more
core   +1 more source

The population-attributable fraction for time-dependent exposures and competing risks - A discussion on estimands

, 2019
The population-attributable fraction (PAF) quantifies the public health impact of a harmful exposure. Despite being a measure of significant importance an estimand accommodating complicated time-to-event data is not clearly defined.
Bailly, Sebastien, Lepape, Alain, Machut, Anais, Savey, Anne, Schumacher, Martin, Timsit, Jean-Francois, von Cube, Maja, Wolkewitz, Martin   +7 more
core   +1 more source

Senescence in vitro and ionising radiations—the human diploid fibroblast model [PDF]

, 1981
The influence of ionising radiations on ageing is still controversial. Since Hayflick established the concept that diploid cells have finite lifespan in vitro, human diploid fibroblast (HDF) cultures have been recognised as a potent experimental model ...
A.F.G. Stevenson, Ban, Beer, Carrel, Cox, Cremer, Cristofalo, Ebeling, Finch, Fukushima, Guichard, Hayflick, Hayflick, Hayflick, Hoehn, Holliday, Holliday, Hopwood, Hug, Kaji, Kirkwood, Kirkwood, Laublin, Lima, Macieira-Coelho, Macieira-Coelho, Macieira-Coelho, Macieira-Coelho, Macieira-Coelho, Maisin, Martin, Namba, Nicholas, Orgel, Orgel, Russ, Schneider, Schneider, Smith, Stevenson, T. Cremer, Walburg, Weismann, Williams, Wilson   +44 more
core   +1 more source

Population attributable fraction of infection-related cancers in Korea

Annals of Oncology, 2011
A number of infectious agents have been classified as human carcinogens. The purpose of the current study was to provide an evidence-based assessment of the burden of infection-related cancers in the Korean population.The population attributable fraction was calculated using infection prevalence data from 1990 or earlier, relative risk estimates from ...
Shin, A., Park, S., Shin, H. R., Park, E. -H., Park, S. K., Oh, J. -K., Lim, M. -K., Choi, B. Y., Boniol, M., Boffetta, P.   +9 more
openaire   +3 more sources

Risk Factors and Population-Attributable Fractions for Incident Hip Osteoarthritis

HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery, 2023
Background: Despite the huge burden of hip osteoarthritis (OA) and the lack of effective treatment, research into the primary prevention of hip OA is in its infancy. Purpose: We sought to evaluate risk factors for incident clinical and incident radiographic hip OA among middle-aged and older adults, to evaluate the importance of risk factors from a ...
Runhaar, Jos, van Berkel, Annemaria C., Agricola, Rintje, van Meurs, Joyce, Bierma-Zeinstra, Sita M.A.   +4 more
openaire   +3 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Diabetes and tuberculosis: the impact of the diabetes epidemic on tuberculosis incidence. [PDF]

, 2007
BACKGROUND: Tuberculosis (TB) remains a major cause of mortality in developing countries, and in these countries diabetes prevalence is increasing rapidly. Diabetes increases the risk of TB.
Dye, Chirstopher, Forouhi, Nita G., Lauer, Jeremy A., Roglic, Gojka, Stevenson, Catherine R., Unwin, Nigel, Williams, Brian G.   +6 more
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source