Results 61 to 70 of about 699,916 (289)

Risk Factors and Population-Attributable Fractions for Incident Hip Osteoarthritis

HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery, 2023
Background: Despite the huge burden of hip osteoarthritis (OA) and the lack of effective treatment, research into the primary prevention of hip OA is in its infancy. Purpose: We sought to evaluate risk factors for incident clinical and incident radiographic hip OA among middle-aged and older adults, to evaluate the importance of risk factors from a ...
Runhaar, Jos, van Berkel, Annemaria C., Agricola, Rintje, van Meurs, Joyce, Bierma-Zeinstra, Sita M.A.   +4 more
openaire   +3 more sources

Population-attributable fraction of risk factors for severe maternal morbidity [PDF]

American Journal of Obstetrics & Gynecology MFM, 2020
Severe maternal morbidity is an important proxy for maternal mortality. Population attributable fraction is the proportion of a disease that is attributable to a given risk factor and can be used to estimate the reduction in the disease that would be anticipated if a risk factor was reduced or eliminated.We sought to determine the population ...
Kyle E. Freese, Lisa M. Bodnar, Maria M. Brooks, Kathleen McTigue, Katherine P. Himes   +4 more
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Potential impact of pre-exposure prophylaxis for female sex workers and men who have sex with men in Bangalore, India: a mathematical modelling study [PDF]

, 2016
Introduction: In Bangalore, new HIV infections of female sex workers and men who have sex with men continue to occur, despite high condom use. Pre-exposure prophylaxis (PrEP) has high anti-HIV efficacy for men who have sex with men.
Anderson, Anna M Foss, Baeten, Baeten, Banandur, Bill & Melinda Gates Foundation., Blower, Boily, Boily, Boily, Brahmam, Damme, Deering, Donnell, Eisingerich, Fern Terris-Prestholt, Foss, Gomez, Granich, Grant, Holly J Prudden, India Health Action Trust, Indian Council of Medical Research & Family Health International., Isac, Jayaraman, Juusola, Karnataka State AIDS Prevention Society., Kate M Mitchell, Low, Lowndes, Lowndes, Maartens, Marie-Claude Boily, Marrazzo, McCormack, Mitchell, Mitchell, Molina, Mukandavire, National AIDS Control Organisation, National Institute of Medical Statistics & National AIDS Control Organization, Peter Vickerman, Phillips, Pickles, Ramesh, Reynold Washington, Saidel, Schneider, Shajy Isac, Shaw, Simoes, Stover, Subramanian P Rajaram, Thigpen, University of Manitoba., Vickerman, Vissers   +56 more
core   +5 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Estimating the burden of disease attributable to high cholesterol in South Africa in 2000 [PDF]

, 2007
Objectives. To estimate the burden of disease attributable to high cholesterol in adults aged 30 years and older in South Africa in 2000. Design. World Health Organization comparative risk assessment (CRA) methodology was followed.
Bradshaw, Debbie, Gaziano, Thomas, Norman, Rosana, South African Comparative Risk Ass, Steyn, Krisela   +4 more
core  

Early discharge of low-risk women from cervical screening [PDF]

, 2001
Background: The Scottish Cervical Screening Programme currently offers three-yearly screening to all women between the ages of 20 and 60. However, previous studies have indicated that well-screened women over the age of 50 are likely to be at low risk of
Ogilvie, D.
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source