Results 161 to 170 of about 23,346,378 (357)

Exploring the relationship between sleep characteristics and cardiovascular biomarkers among adults aged 46–85 years measured in the Doetinchem cohort study

Scientific Reports
We examined the associations between sleep characteristics and cardiovascular biomarkers among middle-aged and older adults from the general population and explored interactions by age and sex.
Laura W. Samson, Hanneke Wijnhoven, W. M. Monique Verschuren, H. Susan J. Picavet   +3 more
doaj   +1 more source

Global burden and trends in premenopausal and postmenopausal breast cancer: a population-based study.

Lancet Global Health, 2020
Emily Heer, A. Harper, N. Escandor, H. Sung, V. McCormack, M. Fidler-Benaoudia   +5 more
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

The Lancet, 2017
S. Ng, H. Shi, N. Hamidi, F. Underwood, Whitney Tang, E. Benchimol, R. Panaccione, Subrata Ghosh, Justin C.Y. Wu, F. Chan, J. Sung, G. Kaplan   +11 more
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Population-based cohort study on comparative effectiveness and safety of biologics in inflammatory bowel disease

Clinical Epidemiology, 2018
Riccardo Di Domenicantonio,1 Francesco Trotta,1 Silvia Cascini,1 Nera Agabiti,1 Anna Kohn,2 Antonio Gasbarrini,3 Marina Davoli,1 Antonio Addis1 1Department of Epidemiology, Lazio Regional Health Service, Rome, Italy; 2IBD Unit, AO San Camillo Forlanini ...
Di Domenicantonio R, Trotta F, Cascini S, Agabiti N, Kohn A, Gasbarrini A, Davoli M, Addis A   +7 more
doaj  

Prevalence, persistence, and severity of 12-month and 30-day DSM-5 disorders in the World Mental Health Hong Kong StudyResearch in context

The Lancet Regional Health. Western Pacific
Summary: Background: The World Mental Health Hong Kong (WMHHK) Study aims to estimate 12-month and 30-day prevalence, persistence, severity, and correlates of DSM-5 anxiety, mood, and externalising disorders in Hong Kong, a densely populated city ...
Corine S.M. Wong, Candi M.C. Leung, Shiyi Wu, Francis P. Flores, Yoona Kim, Xiao Xiao, Solomon B.K. Wong, Wing Chung Chang, Wai Chi Chan, Nancy Xiaonan Yu, Calvin P.W. Cheng, Albert K.K. Chung, Edwin H.M. Lee, Wai Tat Chiu, William G. Axinn, Ronald C. Kessler, Michael Y. Ni   +16 more
doaj   +1 more source

The time to extinction for an SIS-household-epidemic model

, 2009
We analyse a stochastic SIS epidemic amongst a finite population partitioned into households. Since the population is finite, the epidemic will eventually go extinct, i.e., have no more infectives in the population.
A Shwartz, C Bezuidenhout, C Doering, D Griffeath, F Arrigoni, F Ball, G Ghoshal, H Andersson, H Andersson, H Andersson, I Nåsell, J Wallinga, M Lindholm, NM Ferguson, P Neal, P Neal, Peter Neal, R Anderson, R Kryscio, S Cauchemez, S Ethier, T Hagenaars, T Harris, T House, T Liggett, Tom Britton   +25 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Dyslipidemia in diabetes: a population-based study in Bali

International Journal of General Medicine, 2019
Ketut Suastika,1 I Made Siswadi Semadi,1 I Made Pande Dwipayana,1 Made Ratna Saraswati,1 Wira Gotera,1 Anak Agung Gde Budhiarta,1 Kinuyo Matsumoto,2 Naemi Kajiwara,2 Hiroshi Taniguchi31Division of Endocrinology and Metabolism, Department of Internal ...
Suastika K, Semadi IMS, Dwipayana IMP, Saraswati MR, Gotera W, Budhiarta AAG, Matsumoto K, Kajiwara N, Taniguchi H   +8 more
doaj