Results 121 to 130 of about 2,630,928 (351)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

An analysis of Nigerian freshwater fishes: those under threat and conservation options [PDF]

open access: yes, 2005
The study assessed qualitatively the threat status of all nigerian freshwater fishes using such criteria as rarity, size at maturity, mode of reproduction, human population density, habitat degradation, pollution and range of each species among others ...
Bankole, N.O., Olaosebikan, B.D.
core  

Scaling limits of a model for selection at two scales

open access: yes, 2015
The dynamics of a population undergoing selection is a central topic in evolutionary biology. This question is particularly intriguing in the case where selective forces act in opposing directions at two population scales. For example, a fast-replicating
Luo, Shishi, Mattingly, Jonathan C.
core   +2 more sources

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

Mathematical modeling of population problems in biology [PDF]

open access: yes, 2012
Tato bakalářská práce se zabývá modelováním populačních problémů v biologii. Jejím cílem je uvedení základních modelů popisujících dynamiku vývoje jedné nebo dvou populací.
Čampulová, Martina
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Design and construction of a new Drosophila species, D.synthetica, by synthetic regulatory evolution [PDF]

open access: yes, 2011
Here, I merge the principles of synthetic biology^1,2^ and regulatory evolution^3-11^ to create a new species^12-15^ with a minimal set of known elements.
Eduardo Moreno
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

BIOLOGI POPULASI RAJUNGAN (PORTUNUS PELAGICUS) DAN KARAKTERISTIK LINGKUNGAN HABITAT ESENSIALNYA SEBAGAI UPAYA AWAL PERLINDUNGAN DI LAMPUNG TIMUR

open access: yesJurnal Ilmu Pertanian Indonesia, 2014
There are several option management measures in preventing sustainability stock of the blue swimming crab (Portunus pelagicus), i.e., nursery ground conservation. Thus, the objective of this study was to analyses habitat characteristic and its population
Rahmat Kurnia, Mennofatria Boer, Zairion
doaj  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

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