Results 181 to 190 of about 3,325,549 (309)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Exercise and Nutrition for Sarcopenia: A Systematic Review and Meta-Analysis with Subgroup Analysis by Population Characteristics. [PDF]

Nutrients
Yang Y, Pan N, Luo J, Liu Y, Ossowski Z.
europepmc   +1 more source

Population Characteristics and Organ Procurement Organization Performance Metrics.

JAMA Netw Open, 2023
Lopez R, Mohan S, Schold JD.
europepmc   +1 more source

Treatment Patterns and Population Characteristics of Nonpharmacological Management of Chronic Pain in the United States' Medicare Population: A Scoping Review. [PDF]

Innov Aging, 2023
Choudry E, Rofé KL, Konnyu K, Marshall BDL, Shireman TI, Merlin JS, Trivedi AN, Schmidt C, Bhondoekhan F, Moyo P.   +9 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Functional Outcome of De Quervain's Tenosynovitis by Population Characteristics in South Indian Population - A Prospective Study. [PDF]

J Orthop Case Rep
Geethan KSA, Arumugam AK, Nath SHS, Kumar V, Venkatesh R.   +4 more
europepmc   +1 more source

Jail Conditions And Mortality: Death Rates Associated With Turnover, Jail Size, And Population Characteristics. [PDF]

Health Aff (Millwood), 2023
Adler JL, Chen W.
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Non-random aggregations of healthy and unhealthy lifestyles and their population characteristics - pattern recognition in a large population-based cohort. [PDF]

Arch Public Health
Zou Q, Ogaz-González R, Du Y, Duan MJ, Lunter G, Corpeleijn E.   +5 more
europepmc   +1 more source